Recent advances in ZnO-based photosensitizers: Synthesis, modification, and applications in photodynamic cancer therapy
Zinc oxide nanoparticles (ZnO NPs) are important semiconductor materials with interesting photo-responsive properties. During the past, ZnO-based NPs have received considerable attention for photodynamic therapy (PDT) due to their biocompatibility and excellent potential of generating tumor-killing...
| Main Authors: | , , , |
|---|---|
| Format: | Journal Article |
| Language: | English |
| Published: |
ACADEMIC PRESS INC ELSEVIER SCIENCE
2022
|
| Subjects: | |
| Online Access: | http://purl.org/au-research/grants/arc/DP200103332 http://hdl.handle.net/20.500.11937/91974 |
| _version_ | 1848765610152951808 |
|---|---|
| author | Fatima, H. Jin, Z.Y. Shao, Zongping Chen, X.J. |
| author_facet | Fatima, H. Jin, Z.Y. Shao, Zongping Chen, X.J. |
| author_sort | Fatima, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Zinc oxide nanoparticles (ZnO NPs) are important semiconductor materials with interesting photo-responsive properties. During the past, ZnO-based NPs have received considerable attention for photodynamic therapy (PDT) due to their biocompatibility and excellent potential of generating tumor-killing reactive oxygen species (ROS) through gentle photodynamic activation. This article provides a comprehensive review of the recent developments and improvements in optical properties of ZnO NPs as photosensitizers for PDT. The optical properties of ZnO-based photosensitizers are significantly dependent on their charge separation, absorption potential, band gap engineering, and surface area, which can be adjusted/tuned by doping, compositing, and morphology control. Here, we first summarize the recent progress in the charge separation capability, absorption potential, band gap engineering, and surface area of nanosized ZnO-based photosensitizers. Then, morphology control that is closely related to their synthesis method is discussed. Following on, the state-of-art for the ZnO-based NPs in the treatment of hypoxic tumors is comprehensively reviewed. Finally, we provide some outlooks on common targeted therapy methods for more effective tumor killing, including the attachment of small molecules, antibodies, ligands molecules, and receptors to NPs which further improve their selective distribution and targeting, hence improving the therapeutic effectiveness. The current review may provide useful guidance for the researchers who are interested in this promising dynamic cancer treatment technology. |
| first_indexed | 2025-11-14T11:37:59Z |
| format | Journal Article |
| id | curtin-20.500.11937-91974 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:37:59Z |
| publishDate | 2022 |
| publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-919742023-06-08T07:39:30Z Recent advances in ZnO-based photosensitizers: Synthesis, modification, and applications in photodynamic cancer therapy Fatima, H. Jin, Z.Y. Shao, Zongping Chen, X.J. Science & Technology Physical Sciences Chemistry, Physical Chemistry Photodynamic therapy Photosensitizer ZnO nanoparticles Targeted therapy Hypoxic tumor ZINC-OXIDE NANOPARTICLES ENHANCED PHOTOCATALYTIC ACTIVITY MICROWAVE-ASSISTED SYNTHESIS UP-CONVERSION NANOPARTICLES N-DOPED ZNO VISIBLE-LIGHT REACTIVE OXYGEN BAND-GAP OPTICAL-PROPERTIES CELL-DEATH Hypoxic tumor Photodynamic therapy Photosensitizer Targeted therapy ZnO nanoparticles Humans Nanoparticles Neoplasms Photochemotherapy Photosensitizing Agents Zinc Oxide Humans Neoplasms Zinc Oxide Photosensitizing Agents Photochemotherapy Nanoparticles Zinc oxide nanoparticles (ZnO NPs) are important semiconductor materials with interesting photo-responsive properties. During the past, ZnO-based NPs have received considerable attention for photodynamic therapy (PDT) due to their biocompatibility and excellent potential of generating tumor-killing reactive oxygen species (ROS) through gentle photodynamic activation. This article provides a comprehensive review of the recent developments and improvements in optical properties of ZnO NPs as photosensitizers for PDT. The optical properties of ZnO-based photosensitizers are significantly dependent on their charge separation, absorption potential, band gap engineering, and surface area, which can be adjusted/tuned by doping, compositing, and morphology control. Here, we first summarize the recent progress in the charge separation capability, absorption potential, band gap engineering, and surface area of nanosized ZnO-based photosensitizers. Then, morphology control that is closely related to their synthesis method is discussed. Following on, the state-of-art for the ZnO-based NPs in the treatment of hypoxic tumors is comprehensively reviewed. Finally, we provide some outlooks on common targeted therapy methods for more effective tumor killing, including the attachment of small molecules, antibodies, ligands molecules, and receptors to NPs which further improve their selective distribution and targeting, hence improving the therapeutic effectiveness. The current review may provide useful guidance for the researchers who are interested in this promising dynamic cancer treatment technology. 2022 Journal Article http://hdl.handle.net/20.500.11937/91974 10.1016/j.jcis.2022.04.087 English http://purl.org/au-research/grants/arc/DP200103332 http://purl.org/au-research/grants/arc/DP200103315 ACADEMIC PRESS INC ELSEVIER SCIENCE restricted |
| spellingShingle | Science & Technology Physical Sciences Chemistry, Physical Chemistry Photodynamic therapy Photosensitizer ZnO nanoparticles Targeted therapy Hypoxic tumor ZINC-OXIDE NANOPARTICLES ENHANCED PHOTOCATALYTIC ACTIVITY MICROWAVE-ASSISTED SYNTHESIS UP-CONVERSION NANOPARTICLES N-DOPED ZNO VISIBLE-LIGHT REACTIVE OXYGEN BAND-GAP OPTICAL-PROPERTIES CELL-DEATH Hypoxic tumor Photodynamic therapy Photosensitizer Targeted therapy ZnO nanoparticles Humans Nanoparticles Neoplasms Photochemotherapy Photosensitizing Agents Zinc Oxide Humans Neoplasms Zinc Oxide Photosensitizing Agents Photochemotherapy Nanoparticles Fatima, H. Jin, Z.Y. Shao, Zongping Chen, X.J. Recent advances in ZnO-based photosensitizers: Synthesis, modification, and applications in photodynamic cancer therapy |
| title | Recent advances in ZnO-based photosensitizers: Synthesis, modification, and applications in photodynamic cancer therapy |
| title_full | Recent advances in ZnO-based photosensitizers: Synthesis, modification, and applications in photodynamic cancer therapy |
| title_fullStr | Recent advances in ZnO-based photosensitizers: Synthesis, modification, and applications in photodynamic cancer therapy |
| title_full_unstemmed | Recent advances in ZnO-based photosensitizers: Synthesis, modification, and applications in photodynamic cancer therapy |
| title_short | Recent advances in ZnO-based photosensitizers: Synthesis, modification, and applications in photodynamic cancer therapy |
| title_sort | recent advances in zno-based photosensitizers: synthesis, modification, and applications in photodynamic cancer therapy |
| topic | Science & Technology Physical Sciences Chemistry, Physical Chemistry Photodynamic therapy Photosensitizer ZnO nanoparticles Targeted therapy Hypoxic tumor ZINC-OXIDE NANOPARTICLES ENHANCED PHOTOCATALYTIC ACTIVITY MICROWAVE-ASSISTED SYNTHESIS UP-CONVERSION NANOPARTICLES N-DOPED ZNO VISIBLE-LIGHT REACTIVE OXYGEN BAND-GAP OPTICAL-PROPERTIES CELL-DEATH Hypoxic tumor Photodynamic therapy Photosensitizer Targeted therapy ZnO nanoparticles Humans Nanoparticles Neoplasms Photochemotherapy Photosensitizing Agents Zinc Oxide Humans Neoplasms Zinc Oxide Photosensitizing Agents Photochemotherapy Nanoparticles |
| url | http://purl.org/au-research/grants/arc/DP200103332 http://purl.org/au-research/grants/arc/DP200103332 http://hdl.handle.net/20.500.11937/91974 |