Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease
Liver iron accumulation is associated with metabolic conditions such as non-alcoholic fatty liver disease and has been shown to impair health outcomes. This study utilised a combination of traditional molecular biology paired with synchrotron multimodal imaging and revealed iron accumulation is a wo...
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| Format: | Thesis |
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Curtin University
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/91944 |
| _version_ | 1848765601841938432 |
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| author | Kidman, Clinton James |
| author_facet | Kidman, Clinton James |
| author_sort | Kidman, Clinton James |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Liver iron accumulation is associated with metabolic conditions such as non-alcoholic fatty liver disease and has been shown to impair health outcomes. This study utilised a combination of traditional molecular biology paired with synchrotron multimodal imaging and revealed iron accumulation is a wolf in sheep’s clothing, with an initially positive effect of reducing liver fat. However, it appears to radicalise poly-unsaturated fat leading to mitochondrial and peroxisomal dysregulation, furthering liver damage. |
| first_indexed | 2025-11-14T11:37:51Z |
| format | Thesis |
| id | curtin-20.500.11937-91944 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:37:51Z |
| publishDate | 2022 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-919442025-06-16T03:26:28Z Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease Kidman, Clinton James Liver iron accumulation is associated with metabolic conditions such as non-alcoholic fatty liver disease and has been shown to impair health outcomes. This study utilised a combination of traditional molecular biology paired with synchrotron multimodal imaging and revealed iron accumulation is a wolf in sheep’s clothing, with an initially positive effect of reducing liver fat. However, it appears to radicalise poly-unsaturated fat leading to mitochondrial and peroxisomal dysregulation, furthering liver damage. 2022 Thesis http://hdl.handle.net/20.500.11937/91944 Curtin University fulltext |
| spellingShingle | Kidman, Clinton James Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease |
| title | Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease |
| title_full | Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease |
| title_fullStr | Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease |
| title_full_unstemmed | Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease |
| title_short | Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease |
| title_sort | investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease |
| url | http://hdl.handle.net/20.500.11937/91944 |