Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease
Liver iron accumulation is associated with metabolic conditions such as non-alcoholic fatty liver disease and has been shown to impair health outcomes. This study utilised a combination of traditional molecular biology paired with synchrotron multimodal imaging and revealed iron accumulation is a wo...
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| Format: | Thesis |
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Curtin University
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/91944 |
| Summary: | Liver iron accumulation is associated with metabolic conditions such as non-alcoholic fatty liver disease and has been shown to impair health outcomes. This study utilised a combination of traditional molecular biology paired with synchrotron multimodal imaging and revealed iron accumulation is a wolf in sheep’s clothing, with an initially positive effect of reducing liver fat. However, it appears to radicalise poly-unsaturated fat leading to mitochondrial and peroxisomal dysregulation, furthering liver damage. |
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