Hydrogen-bonding 2D coordination polymer for enzyme-free electrochemical glucose sensing
Regular detection of blood glucose levels is a critical indicator for effective diabetes management. Owing to the intrinsic highly sensitive nature of enzymes, the performance of enzymatic glucose sensors is typically impacted by unwanted dependencies on pH, temperature and humidity. Correspondingly...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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ROYAL SOC CHEMISTRY
2022
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/91823 |
| _version_ | 1848765594638221312 |
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| author | Fu, X. Sale, M. Ding, B. Lewis, W. Silvester-Dean, Debbie Ling, C.D. D'Alessandro, D.M. |
| author_facet | Fu, X. Sale, M. Ding, B. Lewis, W. Silvester-Dean, Debbie Ling, C.D. D'Alessandro, D.M. |
| author_sort | Fu, X. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Regular detection of blood glucose levels is a critical indicator for effective diabetes management. Owing to the intrinsic highly sensitive nature of enzymes, the performance of enzymatic glucose sensors is typically impacted by unwanted dependencies on pH, temperature and humidity. Correspondingly, the development of robust enzyme-free glucose sensors is desired due to their potential to improve upon the operational flexibility of traditional systems. In this study, a new coordination polymer (CP) incorporating melamine (Mel), biphenyl-4,4′-dicarboxylate (BPDC2−) co-ligands and Zn(ii) metal nodes, [Zn2(BPDC)1Mel0.5-Mel0.5]·(DMF0.6) {denoted CP1}, was synthesised and characterized for non-enzymatic glucose sensing. Here, the 2D layers are connected by hydrogen bond (H-bond) interactions between the interstitial melamine molecules. In addition to conventional characterization methods, we also used density functional theory (DFT) calculations and variable temperature Raman spectroscopy to computationally and experimentally explore the H-bond interactions in CP1. CP1 was deposited onto a glassy carbon (GC) electrode to facilitate its incorporation into an electrochemical sensing device. When used as an electrochemical glucose sensor, the CP1/GC electrode exhibited accurate clinical performance characteristics, with a wide linear sensing range extending from 5.6 μM to 5.56 mM (R2 = 0.9852) and with a high sensitivity of 517.36 μA mM−1 cm−2. Low sample loadings are a further important advantage associated with this CP-based non-enzymatic glucose sensor. |
| first_indexed | 2025-11-14T11:37:44Z |
| format | Journal Article |
| id | curtin-20.500.11937-91823 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:37:44Z |
| publishDate | 2022 |
| publisher | ROYAL SOC CHEMISTRY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-918232023-06-07T02:24:22Z Hydrogen-bonding 2D coordination polymer for enzyme-free electrochemical glucose sensing Fu, X. Sale, M. Ding, B. Lewis, W. Silvester-Dean, Debbie Ling, C.D. D'Alessandro, D.M. Science & Technology Physical Sciences Chemistry, Multidisciplinary Crystallography Chemistry INITIO MOLECULAR-DYNAMICS TOTAL-ENERGY CALCULATIONS METAL-ORGANIC FRAMEWORKS SENSITIVE DETECTION RESPONSIVE INSULIN CHEMICAL FIXATION FACILE SYNTHESIS NANOPARTICLES COMPOSITE OXIDASE Regular detection of blood glucose levels is a critical indicator for effective diabetes management. Owing to the intrinsic highly sensitive nature of enzymes, the performance of enzymatic glucose sensors is typically impacted by unwanted dependencies on pH, temperature and humidity. Correspondingly, the development of robust enzyme-free glucose sensors is desired due to their potential to improve upon the operational flexibility of traditional systems. In this study, a new coordination polymer (CP) incorporating melamine (Mel), biphenyl-4,4′-dicarboxylate (BPDC2−) co-ligands and Zn(ii) metal nodes, [Zn2(BPDC)1Mel0.5-Mel0.5]·(DMF0.6) {denoted CP1}, was synthesised and characterized for non-enzymatic glucose sensing. Here, the 2D layers are connected by hydrogen bond (H-bond) interactions between the interstitial melamine molecules. In addition to conventional characterization methods, we also used density functional theory (DFT) calculations and variable temperature Raman spectroscopy to computationally and experimentally explore the H-bond interactions in CP1. CP1 was deposited onto a glassy carbon (GC) electrode to facilitate its incorporation into an electrochemical sensing device. When used as an electrochemical glucose sensor, the CP1/GC electrode exhibited accurate clinical performance characteristics, with a wide linear sensing range extending from 5.6 μM to 5.56 mM (R2 = 0.9852) and with a high sensitivity of 517.36 μA mM−1 cm−2. Low sample loadings are a further important advantage associated with this CP-based non-enzymatic glucose sensor. 2022 Journal Article http://hdl.handle.net/20.500.11937/91823 10.1039/d2ce00240j English ROYAL SOC CHEMISTRY fulltext |
| spellingShingle | Science & Technology Physical Sciences Chemistry, Multidisciplinary Crystallography Chemistry INITIO MOLECULAR-DYNAMICS TOTAL-ENERGY CALCULATIONS METAL-ORGANIC FRAMEWORKS SENSITIVE DETECTION RESPONSIVE INSULIN CHEMICAL FIXATION FACILE SYNTHESIS NANOPARTICLES COMPOSITE OXIDASE Fu, X. Sale, M. Ding, B. Lewis, W. Silvester-Dean, Debbie Ling, C.D. D'Alessandro, D.M. Hydrogen-bonding 2D coordination polymer for enzyme-free electrochemical glucose sensing |
| title | Hydrogen-bonding 2D coordination polymer for enzyme-free electrochemical glucose sensing |
| title_full | Hydrogen-bonding 2D coordination polymer for enzyme-free electrochemical glucose sensing |
| title_fullStr | Hydrogen-bonding 2D coordination polymer for enzyme-free electrochemical glucose sensing |
| title_full_unstemmed | Hydrogen-bonding 2D coordination polymer for enzyme-free electrochemical glucose sensing |
| title_short | Hydrogen-bonding 2D coordination polymer for enzyme-free electrochemical glucose sensing |
| title_sort | hydrogen-bonding 2d coordination polymer for enzyme-free electrochemical glucose sensing |
| topic | Science & Technology Physical Sciences Chemistry, Multidisciplinary Crystallography Chemistry INITIO MOLECULAR-DYNAMICS TOTAL-ENERGY CALCULATIONS METAL-ORGANIC FRAMEWORKS SENSITIVE DETECTION RESPONSIVE INSULIN CHEMICAL FIXATION FACILE SYNTHESIS NANOPARTICLES COMPOSITE OXIDASE |
| url | http://hdl.handle.net/20.500.11937/91823 |