Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy
Background: Cardiac power (CP; CP = 0.222 × cardiac output × mean blood pressure) output in patients with heart failure has been studied previously, but its importance in patients with hypertrophic cardiomyopathy (HCM) remains unclear. The present study aimed to explore the role of normalized CP...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
AME Publishing Company
2023
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| Online Access: | https://qims.amegroups.com/article/view/112983 http://hdl.handle.net/20.500.11937/91646 |
| _version_ | 1848765567040749568 |
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| author | Li, Qing Gao, Xuelian Zhou, Zhen Zhang, Hongkai Li, Wenjie Gao, Yifeng Bo, Kairui Wang, Hui Wang, Rui Sun, Zhonghua Xu, L. |
| author_facet | Li, Qing Gao, Xuelian Zhou, Zhen Zhang, Hongkai Li, Wenjie Gao, Yifeng Bo, Kairui Wang, Hui Wang, Rui Sun, Zhonghua Xu, L. |
| author_sort | Li, Qing |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Cardiac power (CP; CP = 0.222 × cardiac output × mean blood pressure) output in
patients with heart failure has been studied previously, but its importance in patients with hypertrophic
cardiomyopathy (HCM) remains unclear. The present study aimed to explore the role of normalized CP
(normalized CP = CP/ventricle mass) in assessing cardiac function in patients with HCM with normal
ejection fraction using cardiac magnetic resonance (CMR).
Methods: This cross-sectional study enrolled 99 patients with HCM who underwent CMR from December
2020 to January 2022 at Beijing Anzhen Hospital, and these patients were classified into heart failure or
non-heart failure subgroups. Meanwhile, a control group comprising 65 gender- and age-matched healthy
volunteers was also enrolled. The baseline clinical characteristics and cardiac functional parameters were
compared between the patients with HCM and the controls, and multivariable linear regression analysis was
performed to analyze the relationship between normalized CP and the relevant factors.
Results: Significantly higher CP (1.19 vs. 1.01 W; P=0.03) but lower normalized CP (0.73 vs. 1.12 W/100 g;
P<0.001) were found in patients with HCM as compared with the controls. Multivariable analysis showed
that HCM correlated well with normalized CP [β=−0.235; 95% confidence interval (CI): −0.341 to −0.129;
P<0.001]. In the HCM group, there were 34 cases with heart failure and 65 with non-heart failure, and the
patients with HCM with heart failure showed similar CP (1.14 vs. 1.24 W; P=0.06) but significantly lower
normalized CP (0.54 vs. 0.78 W/100 g; P<0.001). The correlation analysis of normalized CP and functional
parameters revealed that normalized CP was inversely correlated with left ventricle mass/body surface area
(R=−0.509; 95% CI: −0.646 to −0.341; P<0.001) in patients with HCM.
Conclusions: Normalized CP decreased significantly and was negatively correlated with ventricle mass,
indicating impaired cardiac pump function in patients with HCM. Normalized CP might play a critical role
in detecting and evaluating impaired cardiac pump function in patients with HCM with preserved ejection
fraction. |
| first_indexed | 2025-11-14T11:37:18Z |
| format | Journal Article |
| id | curtin-20.500.11937-91646 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:37:18Z |
| publishDate | 2023 |
| publisher | AME Publishing Company |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-916462023-06-16T05:08:32Z Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy Li, Qing Gao, Xuelian Zhou, Zhen Zhang, Hongkai Li, Wenjie Gao, Yifeng Bo, Kairui Wang, Hui Wang, Rui Sun, Zhonghua Xu, L. Background: Cardiac power (CP; CP = 0.222 × cardiac output × mean blood pressure) output in patients with heart failure has been studied previously, but its importance in patients with hypertrophic cardiomyopathy (HCM) remains unclear. The present study aimed to explore the role of normalized CP (normalized CP = CP/ventricle mass) in assessing cardiac function in patients with HCM with normal ejection fraction using cardiac magnetic resonance (CMR). Methods: This cross-sectional study enrolled 99 patients with HCM who underwent CMR from December 2020 to January 2022 at Beijing Anzhen Hospital, and these patients were classified into heart failure or non-heart failure subgroups. Meanwhile, a control group comprising 65 gender- and age-matched healthy volunteers was also enrolled. The baseline clinical characteristics and cardiac functional parameters were compared between the patients with HCM and the controls, and multivariable linear regression analysis was performed to analyze the relationship between normalized CP and the relevant factors. Results: Significantly higher CP (1.19 vs. 1.01 W; P=0.03) but lower normalized CP (0.73 vs. 1.12 W/100 g; P<0.001) were found in patients with HCM as compared with the controls. Multivariable analysis showed that HCM correlated well with normalized CP [β=−0.235; 95% confidence interval (CI): −0.341 to −0.129; P<0.001]. In the HCM group, there were 34 cases with heart failure and 65 with non-heart failure, and the patients with HCM with heart failure showed similar CP (1.14 vs. 1.24 W; P=0.06) but significantly lower normalized CP (0.54 vs. 0.78 W/100 g; P<0.001). The correlation analysis of normalized CP and functional parameters revealed that normalized CP was inversely correlated with left ventricle mass/body surface area (R=−0.509; 95% CI: −0.646 to −0.341; P<0.001) in patients with HCM. Conclusions: Normalized CP decreased significantly and was negatively correlated with ventricle mass, indicating impaired cardiac pump function in patients with HCM. Normalized CP might play a critical role in detecting and evaluating impaired cardiac pump function in patients with HCM with preserved ejection fraction. 2023 Journal Article http://hdl.handle.net/20.500.11937/91646 https://qims.amegroups.com/article/view/112983 http://creativecommons.org/licenses/by-nc-nd/4.0/ AME Publishing Company fulltext |
| spellingShingle | Li, Qing Gao, Xuelian Zhou, Zhen Zhang, Hongkai Li, Wenjie Gao, Yifeng Bo, Kairui Wang, Hui Wang, Rui Sun, Zhonghua Xu, L. Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy |
| title | Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy |
| title_full | Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy |
| title_fullStr | Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy |
| title_full_unstemmed | Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy |
| title_short | Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy |
| title_sort | impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy |
| url | https://qims.amegroups.com/article/view/112983 http://hdl.handle.net/20.500.11937/91646 |