Is mitochondrial gene expression coordinated or stochastic?
© 2018 Portland Press Ltd. All rights reserved. Mitochondrial biogenesis is intimately dependent on the coordinated expression of the nuclear and mitochondrial genomes that is necessary for the assembly and function of the respiratory complexes to produce most of the energy required by cells. Althou...
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| Format: | Journal Article |
| Language: | English |
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PORTLAND PRESS LTD
2018
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| Online Access: | http://purl.org/au-research/grants/arc/DP170103000 http://hdl.handle.net/20.500.11937/91510 |
| _version_ | 1848765534034722816 |
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| author | Lee, R.G. Rudler, D.L. Rackham, Oliver Filipovska, A. |
| author_facet | Lee, R.G. Rudler, D.L. Rackham, Oliver Filipovska, A. |
| author_sort | Lee, R.G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Portland Press Ltd. All rights reserved. Mitochondrial biogenesis is intimately dependent on the coordinated expression of the nuclear and mitochondrial genomes that is necessary for the assembly and function of the respiratory complexes to produce most of the energy required by cells. Although highly compacted in animals, the mitochondrial genome and its expression are essential for survival, development, and optimal energy production. The machinery that regulates gene expression within mitochondria is localised within the same compartment and, like in their ancestors, the bacteria, this machinery does not use membrane-based compartmentalisation to order the gene expression pathway. Therefore, the lifecycle of mitochondrial RNAs from transcription through processing, maturation, translation to turnover is mediated by a gamut of RNA-binding proteins (RBPs), all contained within the mitochondrial matrix milieu. Recent discoveries indicate that multiple processes regulating RNA metabolism occur at once but since mitochondria have a new complement of RBPs, many evolved de novo from nuclear genes, we are left wondering how co-ordinated are these processes? Here, we review recently identified examples of the co-ordinated and stochastic processes that govern the mitochondrial transcriptome. These new discoveries reveal the complexity of mitochondrial gene expression and the need for its in-depth exploration to understand how these organelles can respond to the energy demands of the cell. |
| first_indexed | 2025-11-14T11:36:46Z |
| format | Journal Article |
| id | curtin-20.500.11937-91510 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:36:46Z |
| publishDate | 2018 |
| publisher | PORTLAND PRESS LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-915102023-05-04T06:19:09Z Is mitochondrial gene expression coordinated or stochastic? Lee, R.G. Rudler, D.L. Rackham, Oliver Filipovska, A. Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology RNA-BINDING PROTEINS TRANSCRIPTION INITIATION MESSENGER-RNAS RIBOSOME GRANULES TRANSLATION COMPLEX MECHANISM SUBUNIT LRPPRC RNA metabolism RNA-binding proteins protein synthesis Animals Cell Nucleus Gene Expression Profiling Gene Expression Regulation Genes, Mitochondrial Genome, Mitochondrial Mitochondria Mitochondrial Proteins RNA RNA, Messenger RNA-Binding Proteins Stochastic Processes Transcription Factors Transcriptome Cell Nucleus Mitochondria Animals RNA-Binding Proteins Mitochondrial Proteins Transcription Factors RNA RNA, Messenger Stochastic Processes Gene Expression Profiling Gene Expression Regulation Genes, Mitochondrial Genome, Mitochondrial Transcriptome © 2018 Portland Press Ltd. All rights reserved. Mitochondrial biogenesis is intimately dependent on the coordinated expression of the nuclear and mitochondrial genomes that is necessary for the assembly and function of the respiratory complexes to produce most of the energy required by cells. Although highly compacted in animals, the mitochondrial genome and its expression are essential for survival, development, and optimal energy production. The machinery that regulates gene expression within mitochondria is localised within the same compartment and, like in their ancestors, the bacteria, this machinery does not use membrane-based compartmentalisation to order the gene expression pathway. Therefore, the lifecycle of mitochondrial RNAs from transcription through processing, maturation, translation to turnover is mediated by a gamut of RNA-binding proteins (RBPs), all contained within the mitochondrial matrix milieu. Recent discoveries indicate that multiple processes regulating RNA metabolism occur at once but since mitochondria have a new complement of RBPs, many evolved de novo from nuclear genes, we are left wondering how co-ordinated are these processes? Here, we review recently identified examples of the co-ordinated and stochastic processes that govern the mitochondrial transcriptome. These new discoveries reveal the complexity of mitochondrial gene expression and the need for its in-depth exploration to understand how these organelles can respond to the energy demands of the cell. 2018 Journal Article http://hdl.handle.net/20.500.11937/91510 10.1042/BST20180174 English http://purl.org/au-research/grants/arc/DP170103000 http://purl.org/au-research/grants/arc/DP180101656 PORTLAND PRESS LTD fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology RNA-BINDING PROTEINS TRANSCRIPTION INITIATION MESSENGER-RNAS RIBOSOME GRANULES TRANSLATION COMPLEX MECHANISM SUBUNIT LRPPRC RNA metabolism RNA-binding proteins protein synthesis Animals Cell Nucleus Gene Expression Profiling Gene Expression Regulation Genes, Mitochondrial Genome, Mitochondrial Mitochondria Mitochondrial Proteins RNA RNA, Messenger RNA-Binding Proteins Stochastic Processes Transcription Factors Transcriptome Cell Nucleus Mitochondria Animals RNA-Binding Proteins Mitochondrial Proteins Transcription Factors RNA RNA, Messenger Stochastic Processes Gene Expression Profiling Gene Expression Regulation Genes, Mitochondrial Genome, Mitochondrial Transcriptome Lee, R.G. Rudler, D.L. Rackham, Oliver Filipovska, A. Is mitochondrial gene expression coordinated or stochastic? |
| title | Is mitochondrial gene expression coordinated or stochastic? |
| title_full | Is mitochondrial gene expression coordinated or stochastic? |
| title_fullStr | Is mitochondrial gene expression coordinated or stochastic? |
| title_full_unstemmed | Is mitochondrial gene expression coordinated or stochastic? |
| title_short | Is mitochondrial gene expression coordinated or stochastic? |
| title_sort | is mitochondrial gene expression coordinated or stochastic? |
| topic | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology RNA-BINDING PROTEINS TRANSCRIPTION INITIATION MESSENGER-RNAS RIBOSOME GRANULES TRANSLATION COMPLEX MECHANISM SUBUNIT LRPPRC RNA metabolism RNA-binding proteins protein synthesis Animals Cell Nucleus Gene Expression Profiling Gene Expression Regulation Genes, Mitochondrial Genome, Mitochondrial Mitochondria Mitochondrial Proteins RNA RNA, Messenger RNA-Binding Proteins Stochastic Processes Transcription Factors Transcriptome Cell Nucleus Mitochondria Animals RNA-Binding Proteins Mitochondrial Proteins Transcription Factors RNA RNA, Messenger Stochastic Processes Gene Expression Profiling Gene Expression Regulation Genes, Mitochondrial Genome, Mitochondrial Transcriptome |
| url | http://purl.org/au-research/grants/arc/DP170103000 http://purl.org/au-research/grants/arc/DP170103000 http://hdl.handle.net/20.500.11937/91510 |