Tighter Ligand Binding Can Compensate for Impaired Stability of an RNA-Binding Protein

Tighter Ligand Binding Can Compensate for Impaired Stability of an RNA-Binding Protein

It has been widely shown that ligand-binding residues, by virtue of their orientation, charge, and solvent exposure, often have a net destabilizing effect on proteins that is offset by stability conferring residues elsewhere in the protein. This structure-function trade-off can constrain possible ad...

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Bibliographic Details
Main Authors: Wallis, C.P., Richman, T.R., Filipovska, A., Rackham, Oliver
Format: Journal Article
Language:English
Published: AMER CHEMICAL SOC 2018
Subjects:
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
23S RIBOSOMAL-RNA
DELETERIOUS MUTATIONS
ANTIBIOTIC-RESISTANCE
MODULAR RECOGNITION
FUNCTION TRADEOFFS
STRUCTURAL BASES
FOLDING ACTIVITY
NUCLEIC-ACIDS
DOMAIN-V
EVOLUTION
Catalytic Domain
Humans
Ligands
Mutagenesis, Site-Directed
Mutation
Protein Binding
Protein Folding
Protein Stability
RNA
RNA-Binding Proteins
Online Access:http://purl.org/au-research/grants/arc/DP140104111
http://hdl.handle.net/20.500.11937/91509

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