Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis
Prenatal exposure to ambient air pollution and extreme temperatures are among the major risk factors of adverse birth outcomes and with potential long-term effects during the life course. Although low-and middle-income countries (LMICs) are most vulnerable, there is limited synthesis of evidence in...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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MDPI
2020
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/91325 |
| _version_ | 1848765508354048000 |
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| author | Sylvester, Dodzi Nyadanu Tessema, Gizachew Mullins, Ben Kumi-Boateng, Bernard Bell, Michelle Lee Pereira, Gavin |
| author_facet | Sylvester, Dodzi Nyadanu Tessema, Gizachew Mullins, Ben Kumi-Boateng, Bernard Bell, Michelle Lee Pereira, Gavin |
| author_sort | Sylvester, Dodzi Nyadanu |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Prenatal exposure to ambient air pollution and extreme temperatures are among the major risk factors of adverse birth outcomes and with potential long-term effects during the life course. Although low-and middle-income countries (LMICs) are most vulnerable, there is limited synthesis of evidence in such settings. This document describes a protocol for both an umbrella review (Systematic Review 1) and a focused systematic review and meta-analysis of studies from LMICs (Systematic Review 2). We will search from start date of each database to present, six major academic databases (PubMed, CINAHL, Scopus, MEDLINE/Ovid, EMBASE/Ovid and Web of Science Core Collection), systematic reviews repositories and references of eligible studies. Additional searches in grey literature will also be conducted. Eligibility criteria include studies of pregnant women exposed to ambient air pollutants and/or extreme temperatures during pregnancy with and without adverse birth outcomes. The umbrella review (Systematic Review 1) will include only previous systematic reviews while Systematic Review 2 will include quantitative observational studies in LMICs. Searches will be restricted to English language using comprehensive search terms to consecutively screen the titles, abstracts and full-texts to select eligible studies. Two independent authors will conduct the study screening and selection, risk of bias assessment and data extraction using JBI SUMARI web-based software. Narrative and semi-quantitative syntheses will be employed for the Systematic Review 1. For Systematic Review 2, we will perform meta-analysis with two alternative meta-analytical methods (quality effect and inverse variance heterogeneity) as well as the classic random effect model. If meta-analysis is infeasible, narrative synthesis will be presented. Confidence in cumulative evidence and the strength of the evidence will be assessed. This protocol is registered with PROSPERO (CRD42020200387). |
| first_indexed | 2025-11-14T11:36:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-91325 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:36:22Z |
| publishDate | 2020 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-913252023-04-19T06:59:24Z Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis Sylvester, Dodzi Nyadanu Tessema, Gizachew Mullins, Ben Kumi-Boateng, Bernard Bell, Michelle Lee Pereira, Gavin Science & Technology Life Sciences & Biomedicine Environmental Sciences Public, Environmental & Occupational Health Environmental Sciences & Ecology ambient air pollution temperature birth outcomes perinatal outcomes umbrella review systematic review meta-analysis low and middle-income countries LMICs FINE PARTICULATE MATTER ENVIRONMENTAL-HEALTH SCIENCE ADVERSE PREGNANCY OUTCOMES PRETERM BIRTH ASSOCIATION EXPOSURES WEIGHT PM2.5 METHODOLOGY QUALITY LMICs ambient air pollution birth outcomes low and middle-income countries meta-analysis perinatal outcomes systematic review temperature umbrella review Air Pollution Female Hot Temperature Humans Meta-Analysis as Topic Parturition Poverty Pregnancy Pregnancy Outcome Pregnant Women Systematic Reviews as Topic Humans Pregnancy Outcome Air Pollution Pregnancy Parturition Poverty Pregnant Women Female Meta-Analysis as Topic Hot Temperature Systematic Reviews as Topic Prenatal exposure to ambient air pollution and extreme temperatures are among the major risk factors of adverse birth outcomes and with potential long-term effects during the life course. Although low-and middle-income countries (LMICs) are most vulnerable, there is limited synthesis of evidence in such settings. This document describes a protocol for both an umbrella review (Systematic Review 1) and a focused systematic review and meta-analysis of studies from LMICs (Systematic Review 2). We will search from start date of each database to present, six major academic databases (PubMed, CINAHL, Scopus, MEDLINE/Ovid, EMBASE/Ovid and Web of Science Core Collection), systematic reviews repositories and references of eligible studies. Additional searches in grey literature will also be conducted. Eligibility criteria include studies of pregnant women exposed to ambient air pollutants and/or extreme temperatures during pregnancy with and without adverse birth outcomes. The umbrella review (Systematic Review 1) will include only previous systematic reviews while Systematic Review 2 will include quantitative observational studies in LMICs. Searches will be restricted to English language using comprehensive search terms to consecutively screen the titles, abstracts and full-texts to select eligible studies. Two independent authors will conduct the study screening and selection, risk of bias assessment and data extraction using JBI SUMARI web-based software. Narrative and semi-quantitative syntheses will be employed for the Systematic Review 1. For Systematic Review 2, we will perform meta-analysis with two alternative meta-analytical methods (quality effect and inverse variance heterogeneity) as well as the classic random effect model. If meta-analysis is infeasible, narrative synthesis will be presented. Confidence in cumulative evidence and the strength of the evidence will be assessed. This protocol is registered with PROSPERO (CRD42020200387). 2020 Journal Article http://hdl.handle.net/20.500.11937/91325 10.3390/ijerph17228658 English http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1173991 http://creativecommons.org/licenses/by/4.0/ MDPI fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Environmental Sciences Public, Environmental & Occupational Health Environmental Sciences & Ecology ambient air pollution temperature birth outcomes perinatal outcomes umbrella review systematic review meta-analysis low and middle-income countries LMICs FINE PARTICULATE MATTER ENVIRONMENTAL-HEALTH SCIENCE ADVERSE PREGNANCY OUTCOMES PRETERM BIRTH ASSOCIATION EXPOSURES WEIGHT PM2.5 METHODOLOGY QUALITY LMICs ambient air pollution birth outcomes low and middle-income countries meta-analysis perinatal outcomes systematic review temperature umbrella review Air Pollution Female Hot Temperature Humans Meta-Analysis as Topic Parturition Poverty Pregnancy Pregnancy Outcome Pregnant Women Systematic Reviews as Topic Humans Pregnancy Outcome Air Pollution Pregnancy Parturition Poverty Pregnant Women Female Meta-Analysis as Topic Hot Temperature Systematic Reviews as Topic Sylvester, Dodzi Nyadanu Tessema, Gizachew Mullins, Ben Kumi-Boateng, Bernard Bell, Michelle Lee Pereira, Gavin Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis |
| title | Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis |
| title_full | Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis |
| title_fullStr | Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis |
| title_full_unstemmed | Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis |
| title_short | Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis |
| title_sort | ambient air pollution, extreme temperatures and birth outcomes: a protocol for an umbrella review, systematic review and meta-analysis |
| topic | Science & Technology Life Sciences & Biomedicine Environmental Sciences Public, Environmental & Occupational Health Environmental Sciences & Ecology ambient air pollution temperature birth outcomes perinatal outcomes umbrella review systematic review meta-analysis low and middle-income countries LMICs FINE PARTICULATE MATTER ENVIRONMENTAL-HEALTH SCIENCE ADVERSE PREGNANCY OUTCOMES PRETERM BIRTH ASSOCIATION EXPOSURES WEIGHT PM2.5 METHODOLOGY QUALITY LMICs ambient air pollution birth outcomes low and middle-income countries meta-analysis perinatal outcomes systematic review temperature umbrella review Air Pollution Female Hot Temperature Humans Meta-Analysis as Topic Parturition Poverty Pregnancy Pregnancy Outcome Pregnant Women Systematic Reviews as Topic Humans Pregnancy Outcome Air Pollution Pregnancy Parturition Poverty Pregnant Women Female Meta-Analysis as Topic Hot Temperature Systematic Reviews as Topic |
| url | http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/91325 |