Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes
The expression of allergic phenotypes involves complex inter-relationships among several Th2 and Th1 cytokines as well as the regulator cytokine interleukin (IL)-10. These direct or indirect interrelationships may distort the true associations of cytokine responses with these phenotypes. In this stu...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/9119 |
| _version_ | 1848745857274347520 |
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| author | Zhang, Guicheng Hayden, C. Goldblatt, J. Holt, P. Le Souëf, P. |
| author_facet | Zhang, Guicheng Hayden, C. Goldblatt, J. Holt, P. Le Souëf, P. |
| author_sort | Zhang, Guicheng |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The expression of allergic phenotypes involves complex inter-relationships among several Th2 and Th1 cytokines as well as the regulator cytokine interleukin (IL)-10. These direct or indirect interrelationships may distort the true associations of cytokine responses with these phenotypes. In this study, we aimed to clarify the effects of the regulatory cytokine IL-10 and Th1 cytokine interferon-gamma (IFN-?) on allergic phenotypes after adjusting for the correlations with Th2 cytokines. After adjusting for Th2 cytokines, IL-10 and IFN-? were protective against atopy. Adjusted levels of IL-10 and IFN-? stimulated with house-dust mite (HDM) were significantly lower in atopics than non-atopics, for IL-10 adjusting for IL-5 (P = 0.002), IL-13 (P = 0.012), IL-9 (P = 0.016), and IL-4 (P = 0.043), and for IFN-? adjusting for IL-5 (P = 0.005), IL-13 (P = 0.005), and IL-9 (P = 0.037). IL-10 and IFN-? levels stimulated with phytohaemagglutinin (PHA) and staphylococcal enterotoxin B (SEB) exhibited a similar pattern. The adjusted levels of IL-10 and IFN-? stimulated with HDM, PHA or SEB were all significantly negatively correlated with total serum IgE, except for IFN-? stimulated with SEB. Levels of Th2 cytokines distort the associations of IL-10 and IFN-? with allergic phenotypes. Removing the covariance with Th2 cytokines, both IL-10 and IFN-? were protective against atopy. |
| first_indexed | 2025-11-14T06:24:01Z |
| format | Journal Article |
| id | curtin-20.500.11937-9119 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:24:01Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-91192017-09-13T14:52:46Z Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes Zhang, Guicheng Hayden, C. Goldblatt, J. Holt, P. Le Souëf, P. The expression of allergic phenotypes involves complex inter-relationships among several Th2 and Th1 cytokines as well as the regulator cytokine interleukin (IL)-10. These direct or indirect interrelationships may distort the true associations of cytokine responses with these phenotypes. In this study, we aimed to clarify the effects of the regulatory cytokine IL-10 and Th1 cytokine interferon-gamma (IFN-?) on allergic phenotypes after adjusting for the correlations with Th2 cytokines. After adjusting for Th2 cytokines, IL-10 and IFN-? were protective against atopy. Adjusted levels of IL-10 and IFN-? stimulated with house-dust mite (HDM) were significantly lower in atopics than non-atopics, for IL-10 adjusting for IL-5 (P = 0.002), IL-13 (P = 0.012), IL-9 (P = 0.016), and IL-4 (P = 0.043), and for IFN-? adjusting for IL-5 (P = 0.005), IL-13 (P = 0.005), and IL-9 (P = 0.037). IL-10 and IFN-? levels stimulated with phytohaemagglutinin (PHA) and staphylococcal enterotoxin B (SEB) exhibited a similar pattern. The adjusted levels of IL-10 and IFN-? stimulated with HDM, PHA or SEB were all significantly negatively correlated with total serum IgE, except for IFN-? stimulated with SEB. Levels of Th2 cytokines distort the associations of IL-10 and IFN-? with allergic phenotypes. Removing the covariance with Th2 cytokines, both IL-10 and IFN-? were protective against atopy. 2011 Journal Article http://hdl.handle.net/20.500.11937/9119 10.5402/2011/405813 fulltext |
| spellingShingle | Zhang, Guicheng Hayden, C. Goldblatt, J. Holt, P. Le Souëf, P. Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes |
| title | Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes |
| title_full | Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes |
| title_fullStr | Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes |
| title_full_unstemmed | Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes |
| title_short | Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes |
| title_sort | th2 cytokine levels distort the association of il-10 and ifn-γ with allergic phenotypes |
| url | http://hdl.handle.net/20.500.11937/9119 |