Recent Advances in Bio-Compatible Oxygen Singlet Generation and Its Tumor Treatment
Light-dependent singlet oxygen (1O2) produced in photodynamic therapy (PDT), is a biologically compatible reactive oxygen species showing the potential to kill tumor cells with fewer side effects on nearby normal healthy cells. The development of a high 1O2 generating photosensitizer is a particular...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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WILEY
2022
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| Online Access: | http://purl.org/au-research/grants/arc/DP200103315 http://hdl.handle.net/20.500.11937/90874 |
| _version_ | 1848765448237088768 |
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| author | Jin, Z.Y. Fatima, Hira Zhang, Y. Shao, Zongping Chen, X.J. |
| author_facet | Jin, Z.Y. Fatima, Hira Zhang, Y. Shao, Zongping Chen, X.J. |
| author_sort | Jin, Z.Y. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Light-dependent singlet oxygen (1O2) produced in photodynamic therapy (PDT), is a biologically compatible reactive oxygen species showing the potential to kill tumor cells with fewer side effects on nearby normal healthy cells. The development of a high 1O2 generating photosensitizer is a particularly demanding research areas. Based on Jablonski's diagram, the photophysical factors influencing the generation of 1O2 are intersystem crossing, triplet quantum yield and life, and the singlet-triplet energy gap. Moreover, nanocarriers are also an emerging research topic with enhanced/localized delivery of photosensitizers to improve the dosage of light and enriched production of 1O2. In this review, the production principle of 1O2 in PDT and its killing mechanism with respect to tumor cells are reviewed. In addition, the progress of PDT has been supplemented in clinical applications in recent years and the emergent preclinical tactics for prospective solutions to these challenges are discussed to improve the effectiveness and usefulness of these procedures. Moreover, the remaining research gaps and future work is outlined. This review is anticipated to heighten the research for developing new strategies for modulating the photophysical properties and improved the delivery of photosensitizers. |
| first_indexed | 2025-11-14T11:35:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-90874 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:35:24Z |
| publishDate | 2022 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-908742023-05-09T04:20:53Z Recent Advances in Bio-Compatible Oxygen Singlet Generation and Its Tumor Treatment Jin, Z.Y. Fatima, Hira Zhang, Y. Shao, Zongping Chen, X.J. Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy intersystem crossing photodynamic therapy singlet oxygen singlet-triplet energy gap triplet quantum yield Triplet quantum life ACTIVATED DELAYED-FLUORESCENCE IMMUNOGENIC CELL-DEATH PHOTOINDUCED ELECTRON-TRANSFER VITRO PHOTODYNAMIC THERAPY DELTA-AMINOLEVULINIC-ACID CONJUGATED GRAPHENE OXIDE RESONANCE ENERGY-TRANSFER EXCITED-STATE PROPERTIES BODIPY-ANTHRACENE DYADS TRIPLET PHOTOSENSITIZERS Light-dependent singlet oxygen (1O2) produced in photodynamic therapy (PDT), is a biologically compatible reactive oxygen species showing the potential to kill tumor cells with fewer side effects on nearby normal healthy cells. The development of a high 1O2 generating photosensitizer is a particularly demanding research areas. Based on Jablonski's diagram, the photophysical factors influencing the generation of 1O2 are intersystem crossing, triplet quantum yield and life, and the singlet-triplet energy gap. Moreover, nanocarriers are also an emerging research topic with enhanced/localized delivery of photosensitizers to improve the dosage of light and enriched production of 1O2. In this review, the production principle of 1O2 in PDT and its killing mechanism with respect to tumor cells are reviewed. In addition, the progress of PDT has been supplemented in clinical applications in recent years and the emergent preclinical tactics for prospective solutions to these challenges are discussed to improve the effectiveness and usefulness of these procedures. Moreover, the remaining research gaps and future work is outlined. This review is anticipated to heighten the research for developing new strategies for modulating the photophysical properties and improved the delivery of photosensitizers. 2022 Journal Article http://hdl.handle.net/20.500.11937/90874 10.1002/adtp.202100176 English http://purl.org/au-research/grants/arc/DP200103315 http://purl.org/au-research/grants/arc/DP200103332 http://creativecommons.org/licenses/by/4.0/ WILEY fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy intersystem crossing photodynamic therapy singlet oxygen singlet-triplet energy gap triplet quantum yield Triplet quantum life ACTIVATED DELAYED-FLUORESCENCE IMMUNOGENIC CELL-DEATH PHOTOINDUCED ELECTRON-TRANSFER VITRO PHOTODYNAMIC THERAPY DELTA-AMINOLEVULINIC-ACID CONJUGATED GRAPHENE OXIDE RESONANCE ENERGY-TRANSFER EXCITED-STATE PROPERTIES BODIPY-ANTHRACENE DYADS TRIPLET PHOTOSENSITIZERS Jin, Z.Y. Fatima, Hira Zhang, Y. Shao, Zongping Chen, X.J. Recent Advances in Bio-Compatible Oxygen Singlet Generation and Its Tumor Treatment |
| title | Recent Advances in Bio-Compatible Oxygen Singlet Generation and Its Tumor Treatment |
| title_full | Recent Advances in Bio-Compatible Oxygen Singlet Generation and Its Tumor Treatment |
| title_fullStr | Recent Advances in Bio-Compatible Oxygen Singlet Generation and Its Tumor Treatment |
| title_full_unstemmed | Recent Advances in Bio-Compatible Oxygen Singlet Generation and Its Tumor Treatment |
| title_short | Recent Advances in Bio-Compatible Oxygen Singlet Generation and Its Tumor Treatment |
| title_sort | recent advances in bio-compatible oxygen singlet generation and its tumor treatment |
| topic | Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy intersystem crossing photodynamic therapy singlet oxygen singlet-triplet energy gap triplet quantum yield Triplet quantum life ACTIVATED DELAYED-FLUORESCENCE IMMUNOGENIC CELL-DEATH PHOTOINDUCED ELECTRON-TRANSFER VITRO PHOTODYNAMIC THERAPY DELTA-AMINOLEVULINIC-ACID CONJUGATED GRAPHENE OXIDE RESONANCE ENERGY-TRANSFER EXCITED-STATE PROPERTIES BODIPY-ANTHRACENE DYADS TRIPLET PHOTOSENSITIZERS |
| url | http://purl.org/au-research/grants/arc/DP200103315 http://purl.org/au-research/grants/arc/DP200103315 http://hdl.handle.net/20.500.11937/90874 |