An exploration into common mechanisms of oxidative damage in models of demyelinating disease and neurotrauma
This thesis explored common mechanisms of oxidative damage in multiple sclerosis and neurotrauma and encompasses work that has been published in four journal articles. Initially, the effectiveness of a combinatorial ion channel inhibitor treatment was established in models of both disorders. The cup...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
Curtin University
2022
|
| Online Access: | http://hdl.handle.net/20.500.11937/90843 |
| _version_ | 1848765441955069952 |
|---|---|
| author | Toomey, Lillian May |
| author_facet | Toomey, Lillian May |
| author_sort | Toomey, Lillian May |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis explored common mechanisms of oxidative damage in multiple sclerosis and neurotrauma and encompasses work that has been published in four journal articles. Initially, the effectiveness of a combinatorial ion channel inhibitor treatment was established in models of both disorders. The cuprizone model of demyelinating disease was also optimised, followed by explorations into the relationship between oxidative DNA damage, cell proliferation and blood vessel dysfunction in models of neurotrauma and multiple sclerosis. |
| first_indexed | 2025-11-14T11:35:19Z |
| format | Thesis |
| id | curtin-20.500.11937-90843 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:35:19Z |
| publishDate | 2022 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-908432023-03-13T04:06:40Z An exploration into common mechanisms of oxidative damage in models of demyelinating disease and neurotrauma Toomey, Lillian May This thesis explored common mechanisms of oxidative damage in multiple sclerosis and neurotrauma and encompasses work that has been published in four journal articles. Initially, the effectiveness of a combinatorial ion channel inhibitor treatment was established in models of both disorders. The cuprizone model of demyelinating disease was also optimised, followed by explorations into the relationship between oxidative DNA damage, cell proliferation and blood vessel dysfunction in models of neurotrauma and multiple sclerosis. 2022 Thesis http://hdl.handle.net/20.500.11937/90843 Curtin University fulltext |
| spellingShingle | Toomey, Lillian May An exploration into common mechanisms of oxidative damage in models of demyelinating disease and neurotrauma |
| title | An exploration into common mechanisms of oxidative damage in
models of demyelinating disease and neurotrauma |
| title_full | An exploration into common mechanisms of oxidative damage in
models of demyelinating disease and neurotrauma |
| title_fullStr | An exploration into common mechanisms of oxidative damage in
models of demyelinating disease and neurotrauma |
| title_full_unstemmed | An exploration into common mechanisms of oxidative damage in
models of demyelinating disease and neurotrauma |
| title_short | An exploration into common mechanisms of oxidative damage in
models of demyelinating disease and neurotrauma |
| title_sort | exploration into common mechanisms of oxidative damage in
models of demyelinating disease and neurotrauma |
| url | http://hdl.handle.net/20.500.11937/90843 |