The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide
High-density lipoproteins (HDLs) are small, protein-lipid particles that transport cholesterol in the blood. HDLs have been proposed to protect against Alzheimer’s Disease via the specific binding and clearance of beta-amyloid, a plaque-forming protein that can accumulate in the brain. This research...
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| Format: | Thesis |
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Curtin University
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/90684 |
| _version_ | 1848765409172389888 |
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| author | Malajczuk, Chris |
| author_facet | Malajczuk, Chris |
| author_sort | Malajczuk, Chris |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | High-density lipoproteins (HDLs) are small, protein-lipid particles that transport cholesterol in the blood. HDLs have been proposed to protect against Alzheimer’s Disease via the specific binding and clearance of beta-amyloid, a plaque-forming protein that can accumulate in the brain. This research aimed to develop and characterise realistic computational models of representative HDLs of different sizes and compositions, to identify the structural and functional differences between particles that inform their capacity to effectively bind beta-amyloid. |
| first_indexed | 2025-11-14T11:34:47Z |
| format | Thesis |
| id | curtin-20.500.11937-90684 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:34:47Z |
| publishDate | 2022 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-906842025-03-11T01:57:12Z The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide Malajczuk, Chris High-density lipoproteins (HDLs) are small, protein-lipid particles that transport cholesterol in the blood. HDLs have been proposed to protect against Alzheimer’s Disease via the specific binding and clearance of beta-amyloid, a plaque-forming protein that can accumulate in the brain. This research aimed to develop and characterise realistic computational models of representative HDLs of different sizes and compositions, to identify the structural and functional differences between particles that inform their capacity to effectively bind beta-amyloid. 2022 Thesis http://hdl.handle.net/20.500.11937/90684 Curtin University fulltext |
| spellingShingle | Malajczuk, Chris The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide |
| title | The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide |
| title_full | The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide |
| title_fullStr | The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide |
| title_full_unstemmed | The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide |
| title_short | The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide |
| title_sort | structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide |
| url | http://hdl.handle.net/20.500.11937/90684 |