A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women.
BACKGROUND: While a number of studies have examined associations between dietary factors and risk of multiple sclerosis (MS), little is known about intakes of inflammation-modulating foods and nutrients and risk of MS. OBJECTIVES: To test associations between the Dietary Inflammatory Index (DII®) an...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/90047 |
| _version_ | 1848765318769410048 |
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| author | Mannino, Adriana Lithander, Fiona E Dunlop, Eleanor Hoare, Samuel Shivappa, Nitin Daly, Alison Phillips, Michael Pereira, Gavin Sherriff, Jill Lucas, Robyn M Ponsonby, Anne-Louise Hébert, James R van der Mei, Ingrid Black, Lucinda Ausimmune Investigator Group |
| author_facet | Mannino, Adriana Lithander, Fiona E Dunlop, Eleanor Hoare, Samuel Shivappa, Nitin Daly, Alison Phillips, Michael Pereira, Gavin Sherriff, Jill Lucas, Robyn M Ponsonby, Anne-Louise Hébert, James R van der Mei, Ingrid Black, Lucinda Ausimmune Investigator Group |
| author_sort | Mannino, Adriana |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | BACKGROUND: While a number of studies have examined associations between dietary factors and risk of multiple sclerosis (MS), little is known about intakes of inflammation-modulating foods and nutrients and risk of MS. OBJECTIVES: To test associations between the Dietary Inflammatory Index (DII®) and risk of a first clinical diagnosis of central nervous system (CNS) demyelination (FCD) (267 cases, 507 controls) using data from the Ausimmune Study. METHODS: The 2003-2006 Ausimmune Study was a multicentre, matched, case-control study examining environmental risk factors for an FCD, a common precursor to MS. The DII is a well-recognised tool that categorises individuals' diets on a continuum from maximally anti-inflammatory to maximally pro-inflammatory. The DII score was calculated from dietary intake data collected using a food frequency questionnaire. Conditional logistic regression models were used to estimate the association between DII and FCD separately for men and women. RESULTS: In women, a higher DII score was associated with increased likelihood of FCD, with a 17% increase in likelihood of FCD per one-unit increase in DII score (adjusted odds ratio 1.17, 95% confidence interval 1.04-1.33). There was no association between DII and FCD in men (adjusted odds ratio 0.88, 95% confidence interval 0.73-1.07). CONCLUSIONS: These findings suggest that a pro-inflammatory diet is associated with an increased likelihood of FCD in women. |
| first_indexed | 2025-11-14T11:33:21Z |
| format | Journal Article |
| id | curtin-20.500.11937-90047 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:33:21Z |
| publishDate | 2022 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-900472023-02-08T03:58:00Z A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women. Mannino, Adriana Lithander, Fiona E Dunlop, Eleanor Hoare, Samuel Shivappa, Nitin Daly, Alison Phillips, Michael Pereira, Gavin Sherriff, Jill Lucas, Robyn M Ponsonby, Anne-Louise Hébert, James R van der Mei, Ingrid Black, Lucinda Ausimmune Investigator Group Ausimmune study Dietary inflammatory index Multiple sclerosis Case-Control Studies Central Nervous System Diet Female Humans Inflammation Male Multiple Sclerosis Risk Factors BACKGROUND: While a number of studies have examined associations between dietary factors and risk of multiple sclerosis (MS), little is known about intakes of inflammation-modulating foods and nutrients and risk of MS. OBJECTIVES: To test associations between the Dietary Inflammatory Index (DII®) and risk of a first clinical diagnosis of central nervous system (CNS) demyelination (FCD) (267 cases, 507 controls) using data from the Ausimmune Study. METHODS: The 2003-2006 Ausimmune Study was a multicentre, matched, case-control study examining environmental risk factors for an FCD, a common precursor to MS. The DII is a well-recognised tool that categorises individuals' diets on a continuum from maximally anti-inflammatory to maximally pro-inflammatory. The DII score was calculated from dietary intake data collected using a food frequency questionnaire. Conditional logistic regression models were used to estimate the association between DII and FCD separately for men and women. RESULTS: In women, a higher DII score was associated with increased likelihood of FCD, with a 17% increase in likelihood of FCD per one-unit increase in DII score (adjusted odds ratio 1.17, 95% confidence interval 1.04-1.33). There was no association between DII and FCD in men (adjusted odds ratio 0.88, 95% confidence interval 0.73-1.07). CONCLUSIONS: These findings suggest that a pro-inflammatory diet is associated with an increased likelihood of FCD in women. 2022 Journal Article http://hdl.handle.net/20.500.11937/90047 10.1016/j.msard.2021.103428 eng http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1173991 http://creativecommons.org/licenses/by-nc-nd/4.0/ fulltext |
| spellingShingle | Ausimmune study Dietary inflammatory index Multiple sclerosis Case-Control Studies Central Nervous System Diet Female Humans Inflammation Male Multiple Sclerosis Risk Factors Mannino, Adriana Lithander, Fiona E Dunlop, Eleanor Hoare, Samuel Shivappa, Nitin Daly, Alison Phillips, Michael Pereira, Gavin Sherriff, Jill Lucas, Robyn M Ponsonby, Anne-Louise Hébert, James R van der Mei, Ingrid Black, Lucinda Ausimmune Investigator Group A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women. |
| title | A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women. |
| title_full | A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women. |
| title_fullStr | A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women. |
| title_full_unstemmed | A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women. |
| title_short | A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women. |
| title_sort | proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women. |
| topic | Ausimmune study Dietary inflammatory index Multiple sclerosis Case-Control Studies Central Nervous System Diet Female Humans Inflammation Male Multiple Sclerosis Risk Factors |
| url | http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/90047 |