A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women.

A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women.

BACKGROUND: While a number of studies have examined associations between dietary factors and risk of multiple sclerosis (MS), little is known about intakes of inflammation-modulating foods and nutrients and risk of MS. OBJECTIVES: To test associations between the Dietary Inflammatory Index (DII®) an...

Full description

Bibliographic Details
Main Authors: Mannino, Adriana, Lithander, Fiona E, Dunlop, Eleanor, Hoare, Samuel, Shivappa, Nitin, Daly, Alison, Phillips, Michael, Pereira, Gavin, Sherriff, Jill, Lucas, Robyn M, Ponsonby, Anne-Louise, Hébert, James R, van der Mei, Ingrid, Black, Lucinda, Ausimmune Investigator Group
Format: Journal Article
Language:English
Published: 2022
Subjects:
Ausimmune study
Dietary inflammatory index
Multiple sclerosis
Case-Control Studies
Central Nervous System
Diet
Female
Humans
Inflammation
Male
Multiple Sclerosis
Risk Factors
Online Access:http://purl.org/au-research/grants/nhmrc/1099655
http://hdl.handle.net/20.500.11937/90047
Description
Summary:BACKGROUND: While a number of studies have examined associations between dietary factors and risk of multiple sclerosis (MS), little is known about intakes of inflammation-modulating foods and nutrients and risk of MS. OBJECTIVES: To test associations between the Dietary Inflammatory Index (DII®) and risk of a first clinical diagnosis of central nervous system (CNS) demyelination (FCD) (267 cases, 507 controls) using data from the Ausimmune Study. METHODS: The 2003-2006 Ausimmune Study was a multicentre, matched, case-control study examining environmental risk factors for an FCD, a common precursor to MS. The DII is a well-recognised tool that categorises individuals' diets on a continuum from maximally anti-inflammatory to maximally pro-inflammatory. The DII score was calculated from dietary intake data collected using a food frequency questionnaire. Conditional logistic regression models were used to estimate the association between DII and FCD separately for men and women. RESULTS: In women, a higher DII score was associated with increased likelihood of FCD, with a 17% increase in likelihood of FCD per one-unit increase in DII score (adjusted odds ratio 1.17, 95% confidence interval 1.04-1.33). There was no association between DII and FCD in men (adjusted odds ratio 0.88, 95% confidence interval 0.73-1.07). CONCLUSIONS: These findings suggest that a pro-inflammatory diet is associated with an increased likelihood of FCD in women.

Similar Items