Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis
To assess the variation in left atrial (LA) and biventricular strain and its prognostic value in the course of suspected myocarditis, this retrospective study included 55 patients with clinically suspected myocarditis who underwent cardiac magnetic resonance (CMR) examinations at baseline and follow...
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| Format: | Journal Article |
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MDPI AG
2023
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| Online Access: | http://hdl.handle.net/20.500.11937/89944 |
| _version_ | 1848765300979269632 |
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| author | Chen, Y. Zhao, W. Zhang, N. Liu, J. Liu, D. Sun, Zhonghua Xu, L. Wen, Z.Y. |
| author_facet | Chen, Y. Zhao, W. Zhang, N. Liu, J. Liu, D. Sun, Zhonghua Xu, L. Wen, Z.Y. |
| author_sort | Chen, Y. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | To assess the variation in left atrial (LA) and biventricular strain and its prognostic value in the course of suspected myocarditis, this retrospective study included 55 patients with clinically suspected myocarditis who underwent cardiac magnetic resonance (CMR) examinations at baseline and follow-up periods. Cine images were used for feature tracking analysis. Paired Student’s t test, McNemar’s test, and Cox proportional hazard regression were used for statistical analysis. The LA total emptying fraction was the only functional index that showed a statistically significant improvement. The initial LA peak’s late negative strain rate (SRa) was the only parameter with a significant predictive power of major adverse cardiac events under univariable (hazard ratio [HR] 2.396, 95% confidence interval [CI] 1.044–5.498, p = 0.039) and multivariable Cox survival analysis when adjusted by LA strain parameters (HR 5.072, 95% CI 1.478–17.404, p = 0.010), LA strain and functional parameters (HR 7.197, 95% CI 1.679–30.846, p = 0.008), and LA and biventricular strain and functional parameters (HR 10.389, 95% CI 2.250–47.977, p = 0.003). Thus, our findings indicate that CMR strain is useful for monitoring LA and ventricular function in suspected myocarditis, that LA function may recover preceding ventricular function changes, and that LA strain may serve as an incremental tool to predict adverse outcomes. |
| first_indexed | 2025-11-14T11:33:04Z |
| format | Journal Article |
| id | curtin-20.500.11937-89944 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:33:04Z |
| publishDate | 2023 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-899442023-02-01T08:23:49Z Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis Chen, Y. Zhao, W. Zhang, N. Liu, J. Liu, D. Sun, Zhonghua Xu, L. Wen, Z.Y. 1102 - Cardiorespiratory Medicine And Haematology 3201 - Cardiovascular medicine and haematology To assess the variation in left atrial (LA) and biventricular strain and its prognostic value in the course of suspected myocarditis, this retrospective study included 55 patients with clinically suspected myocarditis who underwent cardiac magnetic resonance (CMR) examinations at baseline and follow-up periods. Cine images were used for feature tracking analysis. Paired Student’s t test, McNemar’s test, and Cox proportional hazard regression were used for statistical analysis. The LA total emptying fraction was the only functional index that showed a statistically significant improvement. The initial LA peak’s late negative strain rate (SRa) was the only parameter with a significant predictive power of major adverse cardiac events under univariable (hazard ratio [HR] 2.396, 95% confidence interval [CI] 1.044–5.498, p = 0.039) and multivariable Cox survival analysis when adjusted by LA strain parameters (HR 5.072, 95% CI 1.478–17.404, p = 0.010), LA strain and functional parameters (HR 7.197, 95% CI 1.679–30.846, p = 0.008), and LA and biventricular strain and functional parameters (HR 10.389, 95% CI 2.250–47.977, p = 0.003). Thus, our findings indicate that CMR strain is useful for monitoring LA and ventricular function in suspected myocarditis, that LA function may recover preceding ventricular function changes, and that LA strain may serve as an incremental tool to predict adverse outcomes. 2023 Journal Article http://hdl.handle.net/20.500.11937/89944 10.3390/jcm12020457 http://creativecommons.org/licenses/by/4.0/ MDPI AG fulltext |
| spellingShingle | 1102 - Cardiorespiratory Medicine And Haematology 3201 - Cardiovascular medicine and haematology Chen, Y. Zhao, W. Zhang, N. Liu, J. Liu, D. Sun, Zhonghua Xu, L. Wen, Z.Y. Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_full | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_fullStr | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_full_unstemmed | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_short | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_sort | prognostic significance of cardiac magnetic resonance in left atrial and biventricular strain analysis during the follow-up of suspected myocarditis |
| topic | 1102 - Cardiorespiratory Medicine And Haematology 3201 - Cardiovascular medicine and haematology |
| url | http://hdl.handle.net/20.500.11937/89944 |