Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Background: The occurrence and timing of mycobacterial culture conversion is used as a proxy for tuberculosis treatment response. When researchers serially sample sputum during tuberculosis studies, contamination or missed visits leads to missing data points. Traditionally, this is managed by ignori...

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Bibliographic Details
Main Authors: Malatesta, S., Weir, I.R., Weber, S.E., Bouton, T.C., Carney, T., Theron, D., Myers-Franchi, Bronwyn, Horsburgh, C.R., Warren, R.M., Jacobson, K.R., White, L.F.
Format: Journal Article
Language:English
Published: 2022
Subjects:
Culture conversion
Longitudinal missing data
Multiple imputation
Survival analysis
Tuberculosis
Humans
Longitudinal Studies
Data Interpretation, Statistical
Sputum
Bias
Research Design
Online Access:http://hdl.handle.net/20.500.11937/89766

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