Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid
Controlled formation of cocrystals is an important objective in drug development. Here, cocrystallisation of caffeine and 1-hydroxy-2-naphthoic acid was investigated at the interface between two immiscible electrolyte solutions under chemical polarisation. In this way, selective cocrystallisation wa...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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ROYAL SOC CHEMISTRY
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/89592 |
| _version_ | 1848765254468632576 |
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| author | Kaliszczak, M. Durand, P. Wenger, E. Dossot, M. Jones, Franca Arrigan, Damien Herzog, G. |
| author_facet | Kaliszczak, M. Durand, P. Wenger, E. Dossot, M. Jones, Franca Arrigan, Damien Herzog, G. |
| author_sort | Kaliszczak, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Controlled formation of cocrystals is an important objective in drug development. Here, cocrystallisation of caffeine and 1-hydroxy-2-naphthoic acid was investigated at the interface between two immiscible electrolyte solutions under chemical polarisation. In this way, selective cocrystallisation was achieved, as verified by X-ray diffraction and Raman spectroscopy. Positive interfacial potentials favoured the formation of one polymorphic form of caffeine:1-hydroxy-2-naphthoic acid cocrystal. This approach to electrochemically controlled cocrystallisation opens up new possibilities for drug development. |
| first_indexed | 2025-11-14T11:32:20Z |
| format | Journal Article |
| id | curtin-20.500.11937-89592 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:32:20Z |
| publishDate | 2022 |
| publisher | ROYAL SOC CHEMISTRY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-895922023-01-19T07:26:36Z Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid Kaliszczak, M. Durand, P. Wenger, E. Dossot, M. Jones, Franca Arrigan, Damien Herzog, G. Science & Technology Physical Sciences Chemistry, Multidisciplinary Crystallography Chemistry PHARMACEUTICAL COCRYSTALS CAFFEINE INTERFACE CRYSTALLIZATION ION Controlled formation of cocrystals is an important objective in drug development. Here, cocrystallisation of caffeine and 1-hydroxy-2-naphthoic acid was investigated at the interface between two immiscible electrolyte solutions under chemical polarisation. In this way, selective cocrystallisation was achieved, as verified by X-ray diffraction and Raman spectroscopy. Positive interfacial potentials favoured the formation of one polymorphic form of caffeine:1-hydroxy-2-naphthoic acid cocrystal. This approach to electrochemically controlled cocrystallisation opens up new possibilities for drug development. 2022 Journal Article http://hdl.handle.net/20.500.11937/89592 10.1039/d1ce01281a English ROYAL SOC CHEMISTRY fulltext |
| spellingShingle | Science & Technology Physical Sciences Chemistry, Multidisciplinary Crystallography Chemistry PHARMACEUTICAL COCRYSTALS CAFFEINE INTERFACE CRYSTALLIZATION ION Kaliszczak, M. Durand, P. Wenger, E. Dossot, M. Jones, Franca Arrigan, Damien Herzog, G. Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid |
| title | Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid |
| title_full | Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid |
| title_fullStr | Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid |
| title_full_unstemmed | Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid |
| title_short | Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid |
| title_sort | electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid |
| topic | Science & Technology Physical Sciences Chemistry, Multidisciplinary Crystallography Chemistry PHARMACEUTICAL COCRYSTALS CAFFEINE INTERFACE CRYSTALLIZATION ION |
| url | http://hdl.handle.net/20.500.11937/89592 |