Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa
Little is known about gender effects of alcohol and drug use (AOD) among people living with HIV (PLWH) in resource-limited settings. Using multilevel models, we tested whether gender moderated the effect of Khanya, a cognitive-behavioral therapy-based intervention addressing antiretroviral (ART) adh...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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SPRINGER/PLENUM PUBLISHERS
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/89483 |
| _version_ | 1848765229462192128 |
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| author | Belus, J.M. Joska, J.A. Bronsteyn, Y. Rose, A.L. Andersen, L.S. Regenauer, K.S. Myers-Franchi, Bronwyn Hahn, J.A. Orrell, C. Safren, S.A. Magidson, J.F. |
| author_facet | Belus, J.M. Joska, J.A. Bronsteyn, Y. Rose, A.L. Andersen, L.S. Regenauer, K.S. Myers-Franchi, Bronwyn Hahn, J.A. Orrell, C. Safren, S.A. Magidson, J.F. |
| author_sort | Belus, J.M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Little is known about gender effects of alcohol and drug use (AOD) among people living with HIV (PLWH) in resource-limited settings. Using multilevel models, we tested whether gender moderated the effect of Khanya, a cognitive-behavioral therapy-based intervention addressing antiretroviral (ART) adherence and AOD reduction. We enrolled 61 participants from HIV care and examined outcomes at 3- and 6-months compared to enhanced treatment as usual (ETAU). Gender significantly moderated the effect of Khanya on ART adherence (measured using electronically-monitored and biomarker-confirmed adherence), such that women in Khanya had significantly lower ART adherence compared to men in Khanya; no gender differences were found for AOD outcomes. Exploratory trajectory analyses showed men in Khanya and both genders in ETAU had significant reductions in at least one AOD outcome; women in Khanya did not. More research is needed to understand whether a gender lens can support behavioral interventions for PLWH with AOD. Trial registry ClinicalTrials.gov identifier: NCT03529409. Trial registered on May 18, 2018. |
| first_indexed | 2025-11-14T11:31:56Z |
| format | Journal Article |
| id | curtin-20.500.11937-89483 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:31:56Z |
| publishDate | 2022 |
| publisher | SPRINGER/PLENUM PUBLISHERS |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-894832022-10-31T03:23:06Z Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa Belus, J.M. Joska, J.A. Bronsteyn, Y. Rose, A.L. Andersen, L.S. Regenauer, K.S. Myers-Franchi, Bronwyn Hahn, J.A. Orrell, C. Safren, S.A. Magidson, J.F. Science & Technology Social Sciences Life Sciences & Biomedicine Public, Environmental & Occupational Health Social Sciences, Biomedical Biomedical Social Sciences ART adherence Substance use Behavioral intervention Gender differences South Africa INTIMATE PARTNER VIOLENCE ALCOHOL-USE CAPE-TOWN DRINKING NONADHERENCE DISEASE HEALTH DRUGS Little is known about gender effects of alcohol and drug use (AOD) among people living with HIV (PLWH) in resource-limited settings. Using multilevel models, we tested whether gender moderated the effect of Khanya, a cognitive-behavioral therapy-based intervention addressing antiretroviral (ART) adherence and AOD reduction. We enrolled 61 participants from HIV care and examined outcomes at 3- and 6-months compared to enhanced treatment as usual (ETAU). Gender significantly moderated the effect of Khanya on ART adherence (measured using electronically-monitored and biomarker-confirmed adherence), such that women in Khanya had significantly lower ART adherence compared to men in Khanya; no gender differences were found for AOD outcomes. Exploratory trajectory analyses showed men in Khanya and both genders in ETAU had significant reductions in at least one AOD outcome; women in Khanya did not. More research is needed to understand whether a gender lens can support behavioral interventions for PLWH with AOD. Trial registry ClinicalTrials.gov identifier: NCT03529409. Trial registered on May 18, 2018. 2022 Journal Article http://hdl.handle.net/20.500.11937/89483 10.1007/s10461-022-03765-8 English http://creativecommons.org/licenses/by/4.0/ SPRINGER/PLENUM PUBLISHERS fulltext |
| spellingShingle | Science & Technology Social Sciences Life Sciences & Biomedicine Public, Environmental & Occupational Health Social Sciences, Biomedical Biomedical Social Sciences ART adherence Substance use Behavioral intervention Gender differences South Africa INTIMATE PARTNER VIOLENCE ALCOHOL-USE CAPE-TOWN DRINKING NONADHERENCE DISEASE HEALTH DRUGS Belus, J.M. Joska, J.A. Bronsteyn, Y. Rose, A.L. Andersen, L.S. Regenauer, K.S. Myers-Franchi, Bronwyn Hahn, J.A. Orrell, C. Safren, S.A. Magidson, J.F. Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa |
| title | Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa |
| title_full | Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa |
| title_fullStr | Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa |
| title_full_unstemmed | Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa |
| title_short | Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa |
| title_sort | gender moderates results of a randomized clinical trial for the khanya intervention for substance use and art adherence in hiv care in south africa |
| topic | Science & Technology Social Sciences Life Sciences & Biomedicine Public, Environmental & Occupational Health Social Sciences, Biomedical Biomedical Social Sciences ART adherence Substance use Behavioral intervention Gender differences South Africa INTIMATE PARTNER VIOLENCE ALCOHOL-USE CAPE-TOWN DRINKING NONADHERENCE DISEASE HEALTH DRUGS |
| url | http://hdl.handle.net/20.500.11937/89483 |