Deciphering Effects of Uncontrolled Cytomegalovirus Replication on Immune Responses in Cytomegalovirus DNA-Positive Renal Transplant Recipients
Cytomegalovirus (CMV) is a highly prevalent virus and a common cause of morbidity in solid organ transplant patients. It is also known for its long-lasting imprint on the immune system, expanding populations of highly differentiated T cells and natural killer (NK) cells with novel phenotypes. Howeve...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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MARY ANN LIEBERT, INC
2019
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| Subjects: | |
| Online Access: | http://purl.org/au-research/grants/nhmrc/1068652 http://hdl.handle.net/20.500.11937/89473 |
| _version_ | 1848765228383207424 |
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| author | Makwana, Nandini Waters, Shelley Irish, A. Howson, P. Price, Patricia |
| author_facet | Makwana, Nandini Waters, Shelley Irish, A. Howson, P. Price, Patricia |
| author_sort | Makwana, Nandini |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Cytomegalovirus (CMV) is a highly prevalent virus and a common cause of morbidity in solid organ transplant patients. It is also known for its long-lasting imprint on the immune system, expanding populations of highly differentiated T cells and natural killer (NK) cells with novel phenotypes. However, it is unclear whether these cells mark success or failure in the management of an active infection. We assessed CMV reactivation in 54 renal transplant recipients (RTRs) by measuring CMV DNA in plasma samples. Function and phenotype of T cells and NK cells were then assessed in seven RTR with detectable CMV DNA. The patient with highest CMV viral load (P1) displayed increased NK cell function and abundant highly differentiated T cells. We compare P1 with the other six patients and review possible scenarios of cross-regulation between NK cells and T cells. |
| first_indexed | 2025-11-14T11:31:55Z |
| format | Journal Article |
| id | curtin-20.500.11937-89473 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:31:55Z |
| publishDate | 2019 |
| publisher | MARY ANN LIEBERT, INC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-894732023-10-04T06:34:35Z Deciphering Effects of Uncontrolled Cytomegalovirus Replication on Immune Responses in Cytomegalovirus DNA-Positive Renal Transplant Recipients Makwana, Nandini Waters, Shelley Irish, A. Howson, P. Price, Patricia Science & Technology Life Sciences & Biomedicine Immunology Virology cytomegalovirus NK cells T cells renal transplantation NATURAL-KILLER-CELLS MEMORY T-CELLS NK CELLS FCR-GAMMA HLA-E EXPANSION VARIABILITY LIGANDS BINDING UL18 Cytomegalovirus (CMV) is a highly prevalent virus and a common cause of morbidity in solid organ transplant patients. It is also known for its long-lasting imprint on the immune system, expanding populations of highly differentiated T cells and natural killer (NK) cells with novel phenotypes. However, it is unclear whether these cells mark success or failure in the management of an active infection. We assessed CMV reactivation in 54 renal transplant recipients (RTRs) by measuring CMV DNA in plasma samples. Function and phenotype of T cells and NK cells were then assessed in seven RTR with detectable CMV DNA. The patient with highest CMV viral load (P1) displayed increased NK cell function and abundant highly differentiated T cells. We compare P1 with the other six patients and review possible scenarios of cross-regulation between NK cells and T cells. 2019 Journal Article http://hdl.handle.net/20.500.11937/89473 10.1089/vim.2019.0014 English http://purl.org/au-research/grants/nhmrc/1068652 MARY ANN LIEBERT, INC restricted |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Immunology Virology cytomegalovirus NK cells T cells renal transplantation NATURAL-KILLER-CELLS MEMORY T-CELLS NK CELLS FCR-GAMMA HLA-E EXPANSION VARIABILITY LIGANDS BINDING UL18 Makwana, Nandini Waters, Shelley Irish, A. Howson, P. Price, Patricia Deciphering Effects of Uncontrolled Cytomegalovirus Replication on Immune Responses in Cytomegalovirus DNA-Positive Renal Transplant Recipients |
| title | Deciphering Effects of Uncontrolled Cytomegalovirus Replication on Immune Responses in Cytomegalovirus DNA-Positive Renal Transplant Recipients |
| title_full | Deciphering Effects of Uncontrolled Cytomegalovirus Replication on Immune Responses in Cytomegalovirus DNA-Positive Renal Transplant Recipients |
| title_fullStr | Deciphering Effects of Uncontrolled Cytomegalovirus Replication on Immune Responses in Cytomegalovirus DNA-Positive Renal Transplant Recipients |
| title_full_unstemmed | Deciphering Effects of Uncontrolled Cytomegalovirus Replication on Immune Responses in Cytomegalovirus DNA-Positive Renal Transplant Recipients |
| title_short | Deciphering Effects of Uncontrolled Cytomegalovirus Replication on Immune Responses in Cytomegalovirus DNA-Positive Renal Transplant Recipients |
| title_sort | deciphering effects of uncontrolled cytomegalovirus replication on immune responses in cytomegalovirus dna-positive renal transplant recipients |
| topic | Science & Technology Life Sciences & Biomedicine Immunology Virology cytomegalovirus NK cells T cells renal transplantation NATURAL-KILLER-CELLS MEMORY T-CELLS NK CELLS FCR-GAMMA HLA-E EXPANSION VARIABILITY LIGANDS BINDING UL18 |
| url | http://purl.org/au-research/grants/nhmrc/1068652 http://hdl.handle.net/20.500.11937/89473 |