Challenging the conventional interpretation of HCMV seronegativity
The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva, so infection events are likely to be common. Indeed, it is hard to imagine a life without exposure to HCMV. From...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | English |
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MDPI
2021
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| Subjects: | |
| Online Access: | http://purl.org/au-research/grants/nhmrc/1068652 http://hdl.handle.net/20.500.11937/89467 |
| _version_ | 1848765226805100544 |
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| author | Waters, Shelley Lee, Silvia Irish, A. Price, Patricia |
| author_facet | Waters, Shelley Lee, Silvia Irish, A. Price, Patricia |
| author_sort | Waters, Shelley |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva, so infection events are likely to be common. Indeed, it is hard to imagine a life without exposure to HCMV. From 45 seronegative individuals (13 renal transplant recipients, 32 healthy adults), we present seven cases who had detectable HCMV DNA in their blood and/or saliva, or a CMV-encoded homologue of IL-10 (vIL-10) in their plasma. One case displayed NK cells characteristic of CMV infection before her HCMV DNA became undetectable. In other cases, the infection may persist with seroconversion blocked by vIL-10. Future research should seek mechanisms that can prevent an individual from seroconverting despite a persistent HCMV infection, as HCMV vaccines may not work well in such people. |
| first_indexed | 2025-11-14T11:31:53Z |
| format | Journal Article |
| id | curtin-20.500.11937-89467 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:31:53Z |
| publishDate | 2021 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-894672022-11-11T06:39:34Z Challenging the conventional interpretation of HCMV seronegativity Waters, Shelley Lee, Silvia Irish, A. Price, Patricia Science & Technology Life Sciences & Biomedicine Microbiology human cytomegalovirus seronegative NK cells viral IL-10 HUMAN CYTOMEGALOVIRUS TRANSPLANT RECIPIENTS INFECTION CELLS INTERLEUKIN-10 ANTIBODY IFI16 The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva, so infection events are likely to be common. Indeed, it is hard to imagine a life without exposure to HCMV. From 45 seronegative individuals (13 renal transplant recipients, 32 healthy adults), we present seven cases who had detectable HCMV DNA in their blood and/or saliva, or a CMV-encoded homologue of IL-10 (vIL-10) in their plasma. One case displayed NK cells characteristic of CMV infection before her HCMV DNA became undetectable. In other cases, the infection may persist with seroconversion blocked by vIL-10. Future research should seek mechanisms that can prevent an individual from seroconverting despite a persistent HCMV infection, as HCMV vaccines may not work well in such people. 2021 Journal Article http://hdl.handle.net/20.500.11937/89467 10.3390/microorganisms9112382 English http://purl.org/au-research/grants/nhmrc/1068652 http://creativecommons.org/licenses/by/4.0/ MDPI fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Microbiology human cytomegalovirus seronegative NK cells viral IL-10 HUMAN CYTOMEGALOVIRUS TRANSPLANT RECIPIENTS INFECTION CELLS INTERLEUKIN-10 ANTIBODY IFI16 Waters, Shelley Lee, Silvia Irish, A. Price, Patricia Challenging the conventional interpretation of HCMV seronegativity |
| title | Challenging the conventional interpretation of HCMV seronegativity |
| title_full | Challenging the conventional interpretation of HCMV seronegativity |
| title_fullStr | Challenging the conventional interpretation of HCMV seronegativity |
| title_full_unstemmed | Challenging the conventional interpretation of HCMV seronegativity |
| title_short | Challenging the conventional interpretation of HCMV seronegativity |
| title_sort | challenging the conventional interpretation of hcmv seronegativity |
| topic | Science & Technology Life Sciences & Biomedicine Microbiology human cytomegalovirus seronegative NK cells viral IL-10 HUMAN CYTOMEGALOVIRUS TRANSPLANT RECIPIENTS INFECTION CELLS INTERLEUKIN-10 ANTIBODY IFI16 |
| url | http://purl.org/au-research/grants/nhmrc/1068652 http://hdl.handle.net/20.500.11937/89467 |