Influence of MRI-based boundary conditions on type B aortic dissection simulations in false lumen with or without abdominal aorta involvement
Most computational hemodynamic studies of aortic dissections rely on idealized or general boundary conditions. However, numerical simulations that ignore the characteristics of the abdominal branch arteries may not be conducive to accurately observing the hemodynamic changes below the branch arterie...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Frontiers Media
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/89296 |
| _version_ | 1848765198223015936 |
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| author | Liu, D. Wang, X. Zhao, D. Sun, Zhonghua Biekan, J. Wen, Z. Xu, L. Liu, J. |
| author_facet | Liu, D. Wang, X. Zhao, D. Sun, Zhonghua Biekan, J. Wen, Z. Xu, L. Liu, J. |
| author_sort | Liu, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Most computational hemodynamic studies of aortic dissections rely on idealized or general boundary conditions. However, numerical simulations that ignore the characteristics of the abdominal branch arteries may not be conducive to accurately observing the hemodynamic changes below the branch arteries. In the present study, two men (M-I and M-II) with type B aortic dissection (TBAD) underwent arterial-phase computed tomography angiography and four-dimensional flow magnetic resonance imaging (MRI) before and after thoracic endovascular aortic repair (TEVAR). The finite element method was used to simulate the computational fluid dynamic parameters of TBAD [false lumen (FL) with or without visceral artery involvement] under MRI-specific and three idealized boundary conditions in one cardiac cycle. Compared to the results of zero pressure and outflow boundary conditions, the simulations with MRI boundary conditions were closer to the initial MRI data. The pressure difference between TL and FL after TEVAR under the other three boundary conditions was lower than that of the MRI-specific results. The results of the outflow boundary conditions could not characterize the effect of the increased wall pressure near the left renal artery caused by the impact of Tear-1, which raised concerns about the distal organ and limb perfused by FL. After TEVAR, the flow velocity and wall pressure in the FL and the distribution areas of high time average wall shear stress and oscillating shear index were reduced. The difference between the calculation results for different boundary conditions was lower in M-II, wherein FL did not involve the abdominal aorta branches than in M-I. The boundary conditions of the abdominal branch arteries from MRI data might be valuable in elucidating the hemodynamic changes of the descending aorta in TBAD patients before and after treatment, especially those with FL involving the branch arteries. |
| first_indexed | 2025-11-14T11:31:26Z |
| format | Journal Article |
| id | curtin-20.500.11937-89296 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:31:26Z |
| publishDate | 2022 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-892962022-09-28T08:04:07Z Influence of MRI-based boundary conditions on type B aortic dissection simulations in false lumen with or without abdominal aorta involvement Liu, D. Wang, X. Zhao, D. Sun, Zhonghua Biekan, J. Wen, Z. Xu, L. Liu, J. 1102 - Cardiorespiratory Medicine And Haematology 3201 - Cardiovascular medicine and haematology Most computational hemodynamic studies of aortic dissections rely on idealized or general boundary conditions. However, numerical simulations that ignore the characteristics of the abdominal branch arteries may not be conducive to accurately observing the hemodynamic changes below the branch arteries. In the present study, two men (M-I and M-II) with type B aortic dissection (TBAD) underwent arterial-phase computed tomography angiography and four-dimensional flow magnetic resonance imaging (MRI) before and after thoracic endovascular aortic repair (TEVAR). The finite element method was used to simulate the computational fluid dynamic parameters of TBAD [false lumen (FL) with or without visceral artery involvement] under MRI-specific and three idealized boundary conditions in one cardiac cycle. Compared to the results of zero pressure and outflow boundary conditions, the simulations with MRI boundary conditions were closer to the initial MRI data. The pressure difference between TL and FL after TEVAR under the other three boundary conditions was lower than that of the MRI-specific results. The results of the outflow boundary conditions could not characterize the effect of the increased wall pressure near the left renal artery caused by the impact of Tear-1, which raised concerns about the distal organ and limb perfused by FL. After TEVAR, the flow velocity and wall pressure in the FL and the distribution areas of high time average wall shear stress and oscillating shear index were reduced. The difference between the calculation results for different boundary conditions was lower in M-II, wherein FL did not involve the abdominal aorta branches than in M-I. The boundary conditions of the abdominal branch arteries from MRI data might be valuable in elucidating the hemodynamic changes of the descending aorta in TBAD patients before and after treatment, especially those with FL involving the branch arteries. 2022 Journal Article http://hdl.handle.net/20.500.11937/89296 10.3389/fphys.2022.977275 http://creativecommons.org/licenses/by/4.0/ Frontiers Media fulltext |
| spellingShingle | 1102 - Cardiorespiratory Medicine And Haematology 3201 - Cardiovascular medicine and haematology Liu, D. Wang, X. Zhao, D. Sun, Zhonghua Biekan, J. Wen, Z. Xu, L. Liu, J. Influence of MRI-based boundary conditions on type B aortic dissection simulations in false lumen with or without abdominal aorta involvement |
| title | Influence of MRI-based boundary conditions on type B aortic dissection simulations in false lumen with or without abdominal aorta involvement |
| title_full | Influence of MRI-based boundary conditions on type B aortic dissection simulations in false lumen with or without abdominal aorta involvement |
| title_fullStr | Influence of MRI-based boundary conditions on type B aortic dissection simulations in false lumen with or without abdominal aorta involvement |
| title_full_unstemmed | Influence of MRI-based boundary conditions on type B aortic dissection simulations in false lumen with or without abdominal aorta involvement |
| title_short | Influence of MRI-based boundary conditions on type B aortic dissection simulations in false lumen with or without abdominal aorta involvement |
| title_sort | influence of mri-based boundary conditions on type b aortic dissection simulations in false lumen with or without abdominal aorta involvement |
| topic | 1102 - Cardiorespiratory Medicine And Haematology 3201 - Cardiovascular medicine and haematology |
| url | http://hdl.handle.net/20.500.11937/89296 |