Sertraline-Induced Tics: A Case Report and Narrative Review.
This brief report describes the case of a 16-year-old girl who was commenced on sertraline for anxiety and depression, and subsequently developed severe and debilitating motor tics. Cessation of sertraline was associated with the resolution of tics; after this, paroxetine was trialled and well toler...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/89164 |
| _version_ | 1848765175394467840 |
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| author | Arasu, Ramesh Badeshae, Semran Furlong, Yulia Chen, Wai |
| author_facet | Arasu, Ramesh Badeshae, Semran Furlong, Yulia Chen, Wai |
| author_sort | Arasu, Ramesh |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This brief report describes the case of a 16-year-old girl who was commenced on sertraline for anxiety and depression, and subsequently developed severe and debilitating motor tics. Cessation of sertraline was associated with the resolution of tics; after this, paroxetine was trialled and well tolerated with good response of targeted symptoms and without re-emergence of tics. A narrative literature review yielded a retrospective observational study and eight single case reports on selective serotonin receptor inhibitor-induced motor tics (three in adolescents and five in adults). Tics are not commonly considered as a side-effect of SSRIs. This case report is novel is several aspects: the tics emergence was immediate whereas previous cases were delayed; the tics symptoms were measured and quantified by a validated scale; a dose-response relationship was observed; to our knowledge, our case was the first adolescent female reported; and finally, paroxetine was well-tolerated as a substitute, although it is unclear whether the observed tics-sparing effect is co-incidental, ideocratic or can be replicated. |
| first_indexed | 2025-11-14T11:31:04Z |
| format | Journal Article |
| id | curtin-20.500.11937-89164 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:31:04Z |
| publishDate | 2022 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-891642022-08-31T06:39:56Z Sertraline-Induced Tics: A Case Report and Narrative Review. Arasu, Ramesh Badeshae, Semran Furlong, Yulia Chen, Wai adolescence anxiety depression paroxetine selective serotonin reuptake inhibitor sertraline tics tourette’s syndrome This brief report describes the case of a 16-year-old girl who was commenced on sertraline for anxiety and depression, and subsequently developed severe and debilitating motor tics. Cessation of sertraline was associated with the resolution of tics; after this, paroxetine was trialled and well tolerated with good response of targeted symptoms and without re-emergence of tics. A narrative literature review yielded a retrospective observational study and eight single case reports on selective serotonin receptor inhibitor-induced motor tics (three in adolescents and five in adults). Tics are not commonly considered as a side-effect of SSRIs. This case report is novel is several aspects: the tics emergence was immediate whereas previous cases were delayed; the tics symptoms were measured and quantified by a validated scale; a dose-response relationship was observed; to our knowledge, our case was the first adolescent female reported; and finally, paroxetine was well-tolerated as a substitute, although it is unclear whether the observed tics-sparing effect is co-incidental, ideocratic or can be replicated. 2022 Journal Article http://hdl.handle.net/20.500.11937/89164 10.1177/08971900221118015 eng restricted |
| spellingShingle | adolescence anxiety depression paroxetine selective serotonin reuptake inhibitor sertraline tics tourette’s syndrome Arasu, Ramesh Badeshae, Semran Furlong, Yulia Chen, Wai Sertraline-Induced Tics: A Case Report and Narrative Review. |
| title | Sertraline-Induced Tics: A Case Report and Narrative Review. |
| title_full | Sertraline-Induced Tics: A Case Report and Narrative Review. |
| title_fullStr | Sertraline-Induced Tics: A Case Report and Narrative Review. |
| title_full_unstemmed | Sertraline-Induced Tics: A Case Report and Narrative Review. |
| title_short | Sertraline-Induced Tics: A Case Report and Narrative Review. |
| title_sort | sertraline-induced tics: a case report and narrative review. |
| topic | adolescence anxiety depression paroxetine selective serotonin reuptake inhibitor sertraline tics tourette’s syndrome |
| url | http://hdl.handle.net/20.500.11937/89164 |