Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter?
Background: Postpartum haemorrhage (PPH) kits containing uterotonics are used on obstetric units for the timely management of PPH. Visible discolouration of ergometrine and ergometrine-oxytocin injections was observed in PPH kits stored in medical refrigerators on the obstetric unit at our hospital....
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
WILEY
2020
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/88945 |
| _version_ | 1848765120883195904 |
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| author | Donnan, F. Senarathna, Ganga Ware, B. Rawlins, M.D.M. Dontham, C. Chuang, Victor Batty, Kevin |
| author_facet | Donnan, F. Senarathna, Ganga Ware, B. Rawlins, M.D.M. Dontham, C. Chuang, Victor Batty, Kevin |
| author_sort | Donnan, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Postpartum haemorrhage (PPH) kits containing uterotonics are used on obstetric units for the timely management of PPH. Visible discolouration of ergometrine and ergometrine-oxytocin injections was observed in PPH kits stored in medical refrigerators on the obstetric unit at our hospital.
Aim: To investigate the stability of ergometrine and ergometrine-oxytocin injections in PPH kits under simulated clinical storage conditions and to determine the potency of ampoules quarantined from PPH kits on our obstetric unit.
Material and methods: Ergometrine and ergometrine-oxytocin injection ampoules were stored exposed to and protected from light at 4°C and room temperature (25°C) for up to three months, and assayed by high-performance liquid chromatography. Stability was based on the time for the ergometrine or oxytocin concentration to fall to 90% of the original concentration (t90). The potency of quarantined discoloured ampoules also was determined.
Results: Ergometrine was stable at both temperatures for >6 months, when stored protected from light in simulated clinical conditions. When exposed to light, ergometrine was stable for approximately 4 days at 25°C and 10 days at 4°C. Discoloured ergometrine and ergometrine-oxytocin injection ampoules were found to be <90% of the nominal concentration.
Conclusion: Stability of ergometrine in PPH kits is largely unaffected by temperature fluctuations (at 4°C and 25°C) over 6 months when protected from light. Ergometrine and ergometrine-oxytocin ampoules should be inspected prior to use and any discoloured ampoules discarded. |
| first_indexed | 2025-11-14T11:30:12Z |
| format | Journal Article |
| id | curtin-20.500.11937-88945 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:30:12Z |
| publishDate | 2020 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-889452022-08-05T06:56:12Z Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter? Donnan, F. Senarathna, Ganga Ware, B. Rawlins, M.D.M. Dontham, C. Chuang, Victor Batty, Kevin Science & Technology Life Sciences & Biomedicine Obstetrics & Gynecology ergometrine ergometrine-oxytocin kit postpartum haemorrhage stability Background: Postpartum haemorrhage (PPH) kits containing uterotonics are used on obstetric units for the timely management of PPH. Visible discolouration of ergometrine and ergometrine-oxytocin injections was observed in PPH kits stored in medical refrigerators on the obstetric unit at our hospital. Aim: To investigate the stability of ergometrine and ergometrine-oxytocin injections in PPH kits under simulated clinical storage conditions and to determine the potency of ampoules quarantined from PPH kits on our obstetric unit. Material and methods: Ergometrine and ergometrine-oxytocin injection ampoules were stored exposed to and protected from light at 4°C and room temperature (25°C) for up to three months, and assayed by high-performance liquid chromatography. Stability was based on the time for the ergometrine or oxytocin concentration to fall to 90% of the original concentration (t90). The potency of quarantined discoloured ampoules also was determined. Results: Ergometrine was stable at both temperatures for >6 months, when stored protected from light in simulated clinical conditions. When exposed to light, ergometrine was stable for approximately 4 days at 25°C and 10 days at 4°C. Discoloured ergometrine and ergometrine-oxytocin injection ampoules were found to be <90% of the nominal concentration. Conclusion: Stability of ergometrine in PPH kits is largely unaffected by temperature fluctuations (at 4°C and 25°C) over 6 months when protected from light. Ergometrine and ergometrine-oxytocin ampoules should be inspected prior to use and any discoloured ampoules discarded. 2020 Journal Article http://hdl.handle.net/20.500.11937/88945 10.1111/ajo.13046 English WILEY restricted |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Obstetrics & Gynecology ergometrine ergometrine-oxytocin kit postpartum haemorrhage stability Donnan, F. Senarathna, Ganga Ware, B. Rawlins, M.D.M. Dontham, C. Chuang, Victor Batty, Kevin Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter? |
| title | Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter? |
| title_full | Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter? |
| title_fullStr | Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter? |
| title_full_unstemmed | Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter? |
| title_short | Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter? |
| title_sort | ergometrine stability in postpartum haemorrhage kits: does temperature and light matter? |
| topic | Science & Technology Life Sciences & Biomedicine Obstetrics & Gynecology ergometrine ergometrine-oxytocin kit postpartum haemorrhage stability |
| url | http://hdl.handle.net/20.500.11937/88945 |