A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: New insights for improved secondary prophylaxis strategies

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A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: New insights for improved secondary prophylaxis strategies

Background: Benzathine benzylpenicillin G (BPG) is recommended as secondary prophylaxis to prevent recurrence of acute rheumatic fever and subsequent rheumatic heart disease (RHD). Following intramuscular injection, BPG is hydrolysed to benzylpenicillin. Little is known of the pharmacokinetics of be...

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Bibliographic Details
Main Authors:	Hand, R.M., Salman, S., Newall, N., Vine, J., Page-Sharp, Madhu, Bowen, A.C., Gray, K., Baker, A., Kado, J., Joseph, J., Marsh, J., Ramsay, J., Sika-Paotonu, D., Batty, Kevin, Manning, L., Carapetis, J.
Format:	Journal Article
Language:	English
Published:	OXFORD UNIV PRESS 2019
Subjects:	Science & Technology Life Sciences & Biomedicine Infectious Diseases Microbiology Pharmacology & Pharmacy PENICILLIN-G INJECTIONS INFECTION FEVER
Online Access:	http://purl.org/au-research/grants/nhmrc/1088735 http://hdl.handle.net/20.500.11937/88944

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