Epigenetics, cholesterol lowering and diabetes: a comparative study of statins and HDAC inhibitors
Statins are widely used to lower cholesterol and thus reduce cardiovascular risk, although they increase diabetes risk. Butyrate, which is produced by gut bacteria and alters gene expression through epigenetic means, lowers cholesterol and protects against diabetes in animals. This thesis compares t...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/88742 |
| _version_ | 1848765075225051136 |
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| author | Bridgeman, Stephanie Claire |
| author_facet | Bridgeman, Stephanie Claire |
| author_sort | Bridgeman, Stephanie Claire |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Statins are widely used to lower cholesterol and thus reduce cardiovascular risk, although they increase diabetes risk. Butyrate, which is produced by gut bacteria and alters gene expression through epigenetic means, lowers cholesterol and protects against diabetes in animals. This thesis compares the effects of statins and butyrate on epigenetics, cholesterol metabolism and glucose metabolism in cultured cells. Both statins and butyrate lowered cellular cholesterol and impaired insulin secretion, although they acted through different mechanisms. |
| first_indexed | 2025-11-14T11:29:29Z |
| format | Thesis |
| id | curtin-20.500.11937-88742 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:29:29Z |
| publishDate | 2022 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-887422024-06-18T00:24:07Z Epigenetics, cholesterol lowering and diabetes: a comparative study of statins and HDAC inhibitors Bridgeman, Stephanie Claire Statins are widely used to lower cholesterol and thus reduce cardiovascular risk, although they increase diabetes risk. Butyrate, which is produced by gut bacteria and alters gene expression through epigenetic means, lowers cholesterol and protects against diabetes in animals. This thesis compares the effects of statins and butyrate on epigenetics, cholesterol metabolism and glucose metabolism in cultured cells. Both statins and butyrate lowered cellular cholesterol and impaired insulin secretion, although they acted through different mechanisms. 2022 Thesis http://hdl.handle.net/20.500.11937/88742 Curtin University fulltext |
| spellingShingle | Bridgeman, Stephanie Claire Epigenetics, cholesterol lowering and diabetes: a comparative study of statins and HDAC inhibitors |
| title | Epigenetics, cholesterol lowering and diabetes: a
comparative study of statins and HDAC inhibitors |
| title_full | Epigenetics, cholesterol lowering and diabetes: a
comparative study of statins and HDAC inhibitors |
| title_fullStr | Epigenetics, cholesterol lowering and diabetes: a
comparative study of statins and HDAC inhibitors |
| title_full_unstemmed | Epigenetics, cholesterol lowering and diabetes: a
comparative study of statins and HDAC inhibitors |
| title_short | Epigenetics, cholesterol lowering and diabetes: a
comparative study of statins and HDAC inhibitors |
| title_sort | epigenetics, cholesterol lowering and diabetes: a
comparative study of statins and hdac inhibitors |
| url | http://hdl.handle.net/20.500.11937/88742 |