The relationship between sleep and cognition in Parkinson's disease: A meta-analysis
© 2015 Elsevier Ltd. It is well established that sleep disorders have neuropsychological consequences in otherwise healthy people. Studies of night-time sleep problems and cognition in Parkinson's disease (PD), however, paint a mixed picture, with many reporting no relationship between sleep pr...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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W B SAUNDERS CO LTD
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/88173 |
| _version_ | 1848764976277225472 |
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| author | Pushpanathan, M.E. Loftus, Andrea Thomas, M.G. Gasson, Natalie Bucks, R.S. |
| author_facet | Pushpanathan, M.E. Loftus, Andrea Thomas, M.G. Gasson, Natalie Bucks, R.S. |
| author_sort | Pushpanathan, M.E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2015 Elsevier Ltd. It is well established that sleep disorders have neuropsychological consequences in otherwise healthy people. Studies of night-time sleep problems and cognition in Parkinson's disease (PD), however, paint a mixed picture, with many reporting no relationship between sleep problems and neuropsychological performance. This review aimed to meta-analyse this research and to examine the factors underlying these mixed results. A literature search was conducted of published and unpublished studies, resulting in 16 papers that met inclusion criteria. Data were analysed in the domains of: global cognitive function; memory (general, long-term verbal recognition, long-term verbal recall); and executive function (general, shifting, updating, inhibition, generativity, fluid reasoning). There was a significant effect of sleep on global cognitive function, long-term verbal recall, long-term verbal recognition, shifting, updating, generativity, and fluid reasoning. Although there are effects on memory and executive function associated with poor sleep in PD, the effects were driven by a small number of studies. Numerous methodological issues were identified. Further studies are needed reliably to determine whether disturbed sleep impacts on cognition via mechanisms of hypoxia, hypercapnia, sleep fragmentation, chronic sleep debt or decreased REM and/or slow wave sleep in PD, as this may have important clinical implications. |
| first_indexed | 2025-11-14T11:27:54Z |
| format | Journal Article |
| id | curtin-20.500.11937-88173 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:27:54Z |
| publishDate | 2016 |
| publisher | W B SAUNDERS CO LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-881732022-03-31T03:55:02Z The relationship between sleep and cognition in Parkinson's disease: A meta-analysis Pushpanathan, M.E. Loftus, Andrea Thomas, M.G. Gasson, Natalie Bucks, R.S. Parkinson's disease Sleep disorder REM sleep behaviour disorder Cognition Neuropsychology Executive function Memory Review © 2015 Elsevier Ltd. It is well established that sleep disorders have neuropsychological consequences in otherwise healthy people. Studies of night-time sleep problems and cognition in Parkinson's disease (PD), however, paint a mixed picture, with many reporting no relationship between sleep problems and neuropsychological performance. This review aimed to meta-analyse this research and to examine the factors underlying these mixed results. A literature search was conducted of published and unpublished studies, resulting in 16 papers that met inclusion criteria. Data were analysed in the domains of: global cognitive function; memory (general, long-term verbal recognition, long-term verbal recall); and executive function (general, shifting, updating, inhibition, generativity, fluid reasoning). There was a significant effect of sleep on global cognitive function, long-term verbal recall, long-term verbal recognition, shifting, updating, generativity, and fluid reasoning. Although there are effects on memory and executive function associated with poor sleep in PD, the effects were driven by a small number of studies. Numerous methodological issues were identified. Further studies are needed reliably to determine whether disturbed sleep impacts on cognition via mechanisms of hypoxia, hypercapnia, sleep fragmentation, chronic sleep debt or decreased REM and/or slow wave sleep in PD, as this may have important clinical implications. 2016 Journal Article http://hdl.handle.net/20.500.11937/88173 10.1016/j.smrv.2015.04.003 English W B SAUNDERS CO LTD restricted |
| spellingShingle | Parkinson's disease Sleep disorder REM sleep behaviour disorder Cognition Neuropsychology Executive function Memory Review Pushpanathan, M.E. Loftus, Andrea Thomas, M.G. Gasson, Natalie Bucks, R.S. The relationship between sleep and cognition in Parkinson's disease: A meta-analysis |
| title | The relationship between sleep and cognition in Parkinson's disease: A meta-analysis |
| title_full | The relationship between sleep and cognition in Parkinson's disease: A meta-analysis |
| title_fullStr | The relationship between sleep and cognition in Parkinson's disease: A meta-analysis |
| title_full_unstemmed | The relationship between sleep and cognition in Parkinson's disease: A meta-analysis |
| title_short | The relationship between sleep and cognition in Parkinson's disease: A meta-analysis |
| title_sort | relationship between sleep and cognition in parkinson's disease: a meta-analysis |
| topic | Parkinson's disease Sleep disorder REM sleep behaviour disorder Cognition Neuropsychology Executive function Memory Review |
| url | http://hdl.handle.net/20.500.11937/88173 |