Protocol for transcranial direct current stimulation for obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD) is a debilitating disorder with an approximate lifetime prevalence of 1–3%. Despite advances in leading treatment modalities, including pharmacotherapy and psychotherapy, some cases remain treatment resistant. Non-invasive brain stimulation has been explored in th...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
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MDPI
2020
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/88171 |
| _version_ | 1848764975694217216 |
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| author | Green, Peta Loftus, Andrea Anderson, Rebecca |
| author_facet | Green, Peta Loftus, Andrea Anderson, Rebecca |
| author_sort | Green, Peta |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Obsessive-compulsive disorder (OCD) is a debilitating disorder with an approximate lifetime prevalence of 1–3%. Despite advances in leading treatment modalities, including pharmacotherapy and psychotherapy, some cases remain treatment resistant. Non-invasive brain stimulation has been explored in this treatment-resistant population with some promising findings; however, a lack of methodological rigor has reduced the quality of the findings. The current paper presents the protocol for conducting research into the efficacy of transcranial direct current stimulation (tDCS) in the treatment of OCD. A double-blind randomised controlled trial (RCT) will be conducted involving active tDCS vs. sham tDCS on 40 general OCD patients. The intervention consists of 2 mA anodal stimulation over the pre-supplementary motor area (pre-SMA) with the cathode positioned over the orbitofrontal cortex (OFC). Participants will receive 10 sessions of 20 min of either sham-or active-tDCS over 4 weeks. Outcomes will be categorical and dimensional measures of OCD, as well as related secondary clinical measures (depression, anxiety, quality of life), and neurocognitive functions (inhibitory control, cognitive flexibility). |
| first_indexed | 2025-11-14T11:27:54Z |
| format | Journal Article |
| id | curtin-20.500.11937-88171 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:27:54Z |
| publishDate | 2020 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-881712022-03-31T04:13:22Z Protocol for transcranial direct current stimulation for obsessive-compulsive disorder Green, Peta Loftus, Andrea Anderson, Rebecca Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology OCD transcranial direct current stimulation (tDCS) non-invasive brain stimulation neuromodulation obsessive compulsive protocol randomised controlled trial CLINICAL-PRACTICE SHORT-FORM INHIBITION TDCS Obsessive-compulsive disorder (OCD) is a debilitating disorder with an approximate lifetime prevalence of 1–3%. Despite advances in leading treatment modalities, including pharmacotherapy and psychotherapy, some cases remain treatment resistant. Non-invasive brain stimulation has been explored in this treatment-resistant population with some promising findings; however, a lack of methodological rigor has reduced the quality of the findings. The current paper presents the protocol for conducting research into the efficacy of transcranial direct current stimulation (tDCS) in the treatment of OCD. A double-blind randomised controlled trial (RCT) will be conducted involving active tDCS vs. sham tDCS on 40 general OCD patients. The intervention consists of 2 mA anodal stimulation over the pre-supplementary motor area (pre-SMA) with the cathode positioned over the orbitofrontal cortex (OFC). Participants will receive 10 sessions of 20 min of either sham-or active-tDCS over 4 weeks. Outcomes will be categorical and dimensional measures of OCD, as well as related secondary clinical measures (depression, anxiety, quality of life), and neurocognitive functions (inhibitory control, cognitive flexibility). 2020 Journal Article http://hdl.handle.net/20.500.11937/88171 10.3390/brainsci10121008 English MDPI fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology OCD transcranial direct current stimulation (tDCS) non-invasive brain stimulation neuromodulation obsessive compulsive protocol randomised controlled trial CLINICAL-PRACTICE SHORT-FORM INHIBITION TDCS Green, Peta Loftus, Andrea Anderson, Rebecca Protocol for transcranial direct current stimulation for obsessive-compulsive disorder |
| title | Protocol for transcranial direct current stimulation for obsessive-compulsive disorder |
| title_full | Protocol for transcranial direct current stimulation for obsessive-compulsive disorder |
| title_fullStr | Protocol for transcranial direct current stimulation for obsessive-compulsive disorder |
| title_full_unstemmed | Protocol for transcranial direct current stimulation for obsessive-compulsive disorder |
| title_short | Protocol for transcranial direct current stimulation for obsessive-compulsive disorder |
| title_sort | protocol for transcranial direct current stimulation for obsessive-compulsive disorder |
| topic | Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology OCD transcranial direct current stimulation (tDCS) non-invasive brain stimulation neuromodulation obsessive compulsive protocol randomised controlled trial CLINICAL-PRACTICE SHORT-FORM INHIBITION TDCS |
| url | http://hdl.handle.net/20.500.11937/88171 |