Efficacy of probucol on cognitive function in Alzheimer's disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study).

Efficacy of probucol on cognitive function in Alzheimer's disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study).

INTRODUCTION: Preclinical, clinical and epidemiological studies support the hypothesis that aberrant systemic metabolism of amyloid beta (Aβ) in the peripheral circulation is causally related to the development of Alzheimer's disease (AD). Specifically, recent studies suggest that increased pla...

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Bibliographic Details
Main Authors: Lam, Virginie, Clarnette, Roger, Francis, Roslyn, Bynevelt, Michael, Watts, Gerald, Flicker, Leon, Orr, Carolyn F, Loh, Poh, Lautenschlager, Nicola, Reid, Christopher M, Foster, Jonathan K, Dhaliwal, Satvinder S, Robinson, Suzanne, Corti, Emily, Vaccarezza, Mauro, Horgan, Ben, Takechi, Ryu, Mamo, John
Format: Journal Article
Language:English
Published: 2022
Subjects:
clinical trials
dementia
neurobiology
neurology
neuropathology
Online Access:http://hdl.handle.net/20.500.11937/87899

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