Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques
Coronary computed tomography angiography (CCTA) is a widely used imaging modality for diagnosing coronary artery disease (CAD) but is limited by a high false positive rate when evaluating coronary arteries with stents and heavy calcifications. Virtual intravascular endoscopy (VIE) images generated f...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
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MDPI AG
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/87569 |
| _version_ | 1848764927687262208 |
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| author | Wu, P. Tsay, P.K. Sun, Zhonghua Peng, S.J. Lee, C.Y. Hsu, M.Y. Ko, Y.S. Hsieh, I.C. Wen, M.S. Wan, Y.L. |
| author_facet | Wu, P. Tsay, P.K. Sun, Zhonghua Peng, S.J. Lee, C.Y. Hsu, M.Y. Ko, Y.S. Hsieh, I.C. Wen, M.S. Wan, Y.L. |
| author_sort | Wu, P. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Coronary computed tomography angiography (CCTA) is a widely used imaging modality for diagnosing coronary artery disease (CAD) but is limited by a high false positive rate when evaluating coronary arteries with stents and heavy calcifications. Virtual intravascular endoscopy (VIE) images generated from CCTA can be used to qualitatively assess the vascular lumen and might be helpful for overcoming this challenge. In this study, one hundred subjects with coronary stents underwent both CCTA and invasive coronary angiography (ICA). A total of 902 vessel segments were analyzed using CCTA and VIE. The vessel segments were first analyzed on CCTA alone. Then, using VIE, the segments were classified qualitatively as either negative or positive for in-stent restenosis (ISR) or CAD. These results were compared, using ICA as the reference, to determine the added diagnostic value of VIE. Of the 902 analyzed vessel segments, CCTA/VIE had sensitivity, specificity, accuracy, positive predictive value, and negative predictive value (shown in %) of 93.9/90.2, 96.2/98.2, 96.0/97.7, 70.0/83.1, and 99.4/99.0, respectively, in diagnosing ISR or CAD, with significantly improved specificity (p = 0.025), accuracy (p = 0.046), and positive predictive value (p = 0.047). VIE can be a helpful addition to CCTA when evaluating coronary arteries |
| first_indexed | 2025-11-14T11:27:08Z |
| format | Journal Article |
| id | curtin-20.500.11937-87569 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:27:08Z |
| publishDate | 2022 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-875692022-03-03T00:32:33Z Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques Wu, P. Tsay, P.K. Sun, Zhonghua Peng, S.J. Lee, C.Y. Hsu, M.Y. Ko, Y.S. Hsieh, I.C. Wen, M.S. Wan, Y.L. 3201 - Cardiovascular medicine and haematology Coronary computed tomography angiography (CCTA) is a widely used imaging modality for diagnosing coronary artery disease (CAD) but is limited by a high false positive rate when evaluating coronary arteries with stents and heavy calcifications. Virtual intravascular endoscopy (VIE) images generated from CCTA can be used to qualitatively assess the vascular lumen and might be helpful for overcoming this challenge. In this study, one hundred subjects with coronary stents underwent both CCTA and invasive coronary angiography (ICA). A total of 902 vessel segments were analyzed using CCTA and VIE. The vessel segments were first analyzed on CCTA alone. Then, using VIE, the segments were classified qualitatively as either negative or positive for in-stent restenosis (ISR) or CAD. These results were compared, using ICA as the reference, to determine the added diagnostic value of VIE. Of the 902 analyzed vessel segments, CCTA/VIE had sensitivity, specificity, accuracy, positive predictive value, and negative predictive value (shown in %) of 93.9/90.2, 96.2/98.2, 96.0/97.7, 70.0/83.1, and 99.4/99.0, respectively, in diagnosing ISR or CAD, with significantly improved specificity (p = 0.025), accuracy (p = 0.046), and positive predictive value (p = 0.047). VIE can be a helpful addition to CCTA when evaluating coronary arteries 2022 Journal Article http://hdl.handle.net/20.500.11937/87569 10.3390/diagnostics12020390 http://creativecommons.org/licenses/by/4.0/ MDPI AG fulltext |
| spellingShingle | 3201 - Cardiovascular medicine and haematology Wu, P. Tsay, P.K. Sun, Zhonghua Peng, S.J. Lee, C.Y. Hsu, M.Y. Ko, Y.S. Hsieh, I.C. Wen, M.S. Wan, Y.L. Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques |
| title | Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques |
| title_full | Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques |
| title_fullStr | Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques |
| title_full_unstemmed | Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques |
| title_short | Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques |
| title_sort | added value of computed tomography virtual intravascular endoscopy in the evaluation of coronary arteries with stents or plaques |
| topic | 3201 - Cardiovascular medicine and haematology |
| url | http://hdl.handle.net/20.500.11937/87569 |