Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation
A 74-year-old female subject with suboptimal management of episodic tension headache was treated with a daily dose of 1.5 g l-arginine and 1.2 g aged garlic extract (AGE). The aim of the intervention was to promote vasodilation of parenchymal cerebral blood vessels. Within 6 weeks of commencing trea...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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SPRINGERNATURE
2021
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/87166 |
| _version_ | 1848764902246711296 |
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| author | Chaliha, Devahuti Vaccarezza, Mauro Lam, Virginie Takechi, Ryu Mamo, John |
| author_facet | Chaliha, Devahuti Vaccarezza, Mauro Lam, Virginie Takechi, Ryu Mamo, John |
| author_sort | Chaliha, Devahuti |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A 74-year-old female subject with suboptimal management of episodic tension headache was treated with a daily dose of 1.5 g l-arginine and 1.2 g aged garlic extract (AGE). The aim of the intervention was to promote vasodilation of parenchymal cerebral blood vessels. Within 6 weeks of commencing treatment, her self-reported symptoms improved markedly and were sustained at 2 years following commencement. We propose that the putative beneficial effect of l-arginine and AGE in this patient is because of the well-established systemic vasodilatory effects of l-arginine and aged garlic extract. On the hypothesis that migraine is precipitated by cerebral microvascular constriction, we recommend a double-blind randomised controlled trial to clinically test this hypothesis in migraine patients. |
| first_indexed | 2025-11-14T11:26:44Z |
| format | Journal Article |
| id | curtin-20.500.11937-87166 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:26:44Z |
| publishDate | 2021 |
| publisher | SPRINGERNATURE |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-871662022-01-12T01:27:57Z Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation Chaliha, Devahuti Vaccarezza, Mauro Lam, Virginie Takechi, Ryu Mamo, John Science & Technology Life Sciences & Biomedicine Nutrition & Dietetics ENDOTHELIAL FUNCTION ESTROGEN A 74-year-old female subject with suboptimal management of episodic tension headache was treated with a daily dose of 1.5 g l-arginine and 1.2 g aged garlic extract (AGE). The aim of the intervention was to promote vasodilation of parenchymal cerebral blood vessels. Within 6 weeks of commencing treatment, her self-reported symptoms improved markedly and were sustained at 2 years following commencement. We propose that the putative beneficial effect of l-arginine and AGE in this patient is because of the well-established systemic vasodilatory effects of l-arginine and aged garlic extract. On the hypothesis that migraine is precipitated by cerebral microvascular constriction, we recommend a double-blind randomised controlled trial to clinically test this hypothesis in migraine patients. 2021 Journal Article http://hdl.handle.net/20.500.11937/87166 10.1038/s41430-021-00962-x English SPRINGERNATURE restricted |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Nutrition & Dietetics ENDOTHELIAL FUNCTION ESTROGEN Chaliha, Devahuti Vaccarezza, Mauro Lam, Virginie Takechi, Ryu Mamo, John Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation |
| title | Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation |
| title_full | Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation |
| title_fullStr | Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation |
| title_full_unstemmed | Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation |
| title_short | Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation |
| title_sort | attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation |
| topic | Science & Technology Life Sciences & Biomedicine Nutrition & Dietetics ENDOTHELIAL FUNCTION ESTROGEN |
| url | http://hdl.handle.net/20.500.11937/87166 |