Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort
Objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors have been associated with lower incidence rates of some cancers. Because asbestos can cause chronic inflammation at the pleural and peritoneal surfaces we hypothesised that NSAID and COX-2 inhibitors would inhibit the de...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Elsevier Ireland Ltd
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/8706 |
| _version_ | 1848745736598978560 |
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| author | Robinson, C. Alfonso, Helman Woo, S. Olsen, N. Musk, A. Robinson, B. Nowak, A. Lake, R. |
| author_facet | Robinson, C. Alfonso, Helman Woo, S. Olsen, N. Musk, A. Robinson, B. Nowak, A. Lake, R. |
| author_sort | Robinson, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors have been associated with lower incidence rates of some cancers. Because asbestos can cause chronic inflammation at the pleural and peritoneal surfaces we hypothesised that NSAID and COX-2 inhibitors would inhibit the development of asbestos-induced mesothelioma. Materials and methods: A murine model of asbestos-induced mesothelioma was used to test this hypothesis by providing the NSAID, aspirin, daily in the feed at 50. mg/kg or 250. mg/kg. In a parallel study, the relationship between the use of NSAID and COX-2 inhibitors and mesothelioma was investigated in a human cohort of 1738 asbestos exposed people living or working in Wittenoom, Western Australia (a crocidolite mine site). Results: Aspirin did not alter the rate of disease development or increase the length of time that mice survived. Aspirin had a small but significant effect on disease latency (the time between asbestos exposure and first evidence of disease; p < 0.05) but disease progression was not affected by the continued presence of the drug. In the Wittenoom cohort, individuals who reported use of NSAIDs, COX-2 inhibitors or both did not have a lower incidence of mesothelioma (HR = 0.85; 95% CI = 0.53-1.37, p= 0.50), (HR = 0.69; 95% CI = 0.21-2.30, p= 0.55) and (HR = 0.43; 95% CI = 0.16-1.13, p= 0.087) respectively. Conclusion: We conclude that NSAIDs and COX-2 inhibitors do not moderate mesothelioma development or progression in a human cohort exposed to asbestos and this result is confirmed in an autochthonous mouse model. |
| first_indexed | 2025-11-14T06:22:06Z |
| format | Journal Article |
| id | curtin-20.500.11937-8706 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:22:06Z |
| publishDate | 2014 |
| publisher | Elsevier Ireland Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-87062017-09-13T14:52:04Z Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort Robinson, C. Alfonso, Helman Woo, S. Olsen, N. Musk, A. Robinson, B. Nowak, A. Lake, R. Objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors have been associated with lower incidence rates of some cancers. Because asbestos can cause chronic inflammation at the pleural and peritoneal surfaces we hypothesised that NSAID and COX-2 inhibitors would inhibit the development of asbestos-induced mesothelioma. Materials and methods: A murine model of asbestos-induced mesothelioma was used to test this hypothesis by providing the NSAID, aspirin, daily in the feed at 50. mg/kg or 250. mg/kg. In a parallel study, the relationship between the use of NSAID and COX-2 inhibitors and mesothelioma was investigated in a human cohort of 1738 asbestos exposed people living or working in Wittenoom, Western Australia (a crocidolite mine site). Results: Aspirin did not alter the rate of disease development or increase the length of time that mice survived. Aspirin had a small but significant effect on disease latency (the time between asbestos exposure and first evidence of disease; p < 0.05) but disease progression was not affected by the continued presence of the drug. In the Wittenoom cohort, individuals who reported use of NSAIDs, COX-2 inhibitors or both did not have a lower incidence of mesothelioma (HR = 0.85; 95% CI = 0.53-1.37, p= 0.50), (HR = 0.69; 95% CI = 0.21-2.30, p= 0.55) and (HR = 0.43; 95% CI = 0.16-1.13, p= 0.087) respectively. Conclusion: We conclude that NSAIDs and COX-2 inhibitors do not moderate mesothelioma development or progression in a human cohort exposed to asbestos and this result is confirmed in an autochthonous mouse model. 2014 Journal Article http://hdl.handle.net/20.500.11937/8706 10.1016/j.lungcan.2014.08.005 Elsevier Ireland Ltd restricted |
| spellingShingle | Robinson, C. Alfonso, Helman Woo, S. Olsen, N. Musk, A. Robinson, B. Nowak, A. Lake, R. Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort |
| title | Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort |
| title_full | Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort |
| title_fullStr | Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort |
| title_full_unstemmed | Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort |
| title_short | Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort |
| title_sort | effect of nsaids and cox-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort |
| url | http://hdl.handle.net/20.500.11937/8706 |