Investigating the role of inflammatory and neuronal repair genes in the neurological sequelae of HIV infection
This thesis investigates factors that influence whether an HIV patient experiences sensory neuropathy or neurocognitive decline. I studied patients treated in Indonesia and South Africa. Genotypes that affect inflammation and neuronal repair influenced susceptibility to both neurological conditions....
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| Format: | Thesis |
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Curtin University
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/86954 |
| _version_ | 1848764888677089280 |
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| author | Gaff, Jessica Anne |
| author_facet | Gaff, Jessica Anne |
| author_sort | Gaff, Jessica Anne |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis investigates factors that influence whether an HIV patient experiences sensory neuropathy or neurocognitive decline. I studied patients treated in Indonesia and South Africa. Genotypes that affect inflammation and neuronal repair influenced susceptibility to both neurological conditions. I used skin biopsies from Indonesian patients to show that proteins encoded by these genes are expressed by inflammatory cells around nerves damaged by neuropathy. This thesis identifies individuals at risk and provides insight into pathogenic mechanisms. |
| first_indexed | 2025-11-14T11:26:31Z |
| format | Thesis |
| id | curtin-20.500.11937-86954 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:26:31Z |
| publishDate | 2021 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-869542024-01-08T07:08:18Z Investigating the role of inflammatory and neuronal repair genes in the neurological sequelae of HIV infection Gaff, Jessica Anne This thesis investigates factors that influence whether an HIV patient experiences sensory neuropathy or neurocognitive decline. I studied patients treated in Indonesia and South Africa. Genotypes that affect inflammation and neuronal repair influenced susceptibility to both neurological conditions. I used skin biopsies from Indonesian patients to show that proteins encoded by these genes are expressed by inflammatory cells around nerves damaged by neuropathy. This thesis identifies individuals at risk and provides insight into pathogenic mechanisms. 2021 Thesis http://hdl.handle.net/20.500.11937/86954 Curtin University fulltext |
| spellingShingle | Gaff, Jessica Anne Investigating the role of inflammatory and neuronal repair genes in the neurological sequelae of HIV infection |
| title | Investigating the role of inflammatory and neuronal repair genes in the
neurological sequelae of HIV infection |
| title_full | Investigating the role of inflammatory and neuronal repair genes in the
neurological sequelae of HIV infection |
| title_fullStr | Investigating the role of inflammatory and neuronal repair genes in the
neurological sequelae of HIV infection |
| title_full_unstemmed | Investigating the role of inflammatory and neuronal repair genes in the
neurological sequelae of HIV infection |
| title_short | Investigating the role of inflammatory and neuronal repair genes in the
neurological sequelae of HIV infection |
| title_sort | investigating the role of inflammatory and neuronal repair genes in the
neurological sequelae of hiv infection |
| url | http://hdl.handle.net/20.500.11937/86954 |