Tuberculosis related disability: a systematic review and meta-analysis
Background: The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Therefore, we aimed to quantify the prevalence and types of TB-related disabilities...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | http://purl.org/au-research/grants/nhmrc/1121611 http://hdl.handle.net/20.500.11937/86450 |
| _version_ | 1848764825853755392 |
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| author | Alene, Kefyalew Wangdi, K. Colquhoun, S. Chani, K. Islam, T. Rahevar, K. Morishita, F. Byrne, A. Clark, J. Viney, K. |
| author_facet | Alene, Kefyalew Wangdi, K. Colquhoun, S. Chani, K. Islam, T. Rahevar, K. Morishita, F. Byrne, A. Clark, J. Viney, K. |
| author_sort | Alene, Kefyalew |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Therefore, we aimed to quantify the prevalence and types of TB-related disabilities.
Methods: We performed a systematic review of TB-related disabilities. The pooled prevalence of disabilities was calculated using the inverse variance heterogeneity model. The maps of the proportions of common types of disabilities by country income level were created.
Results: We included a total of 131 studies (217,475 patients) that were conducted in 49 countries. The most common type of disabilities were mental health disorders (23.1%), respiratory impairment (20.7%), musculoskeletal impairment (17.1%), hearing impairment (14.5%), visual impairment (9.8%), renal impairment (5.7%), and neurological impairment (1.6%). The prevalence of respiratory impairment (61.2%) and mental health disorders (42.0%) was highest in low-income countries while neurological impairment was highest in lower middle-income countries (25.6%). Drug-resistant TB was associated with respiratory (58.7%), neurological (37.2%), and hearing impairments (25.0%) and mental health disorders (26.0%), respectively.
Conclusions: TB-related disabilities were frequently reported. More uniform reporting tools for TB-related disability and further research to better quantify and mitigate it are urgently needed. Prospero registration number: CRD42019147488 |
| first_indexed | 2025-11-14T11:25:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-86450 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:25:31Z |
| publishDate | 2021 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-864502021-11-29T01:20:13Z Tuberculosis related disability: a systematic review and meta-analysis Alene, Kefyalew Wangdi, K. Colquhoun, S. Chani, K. Islam, T. Rahevar, K. Morishita, F. Byrne, A. Clark, J. Viney, K. Disability Impairment Meta-analysis Treatment Tuberculosis Disabled Persons Humans Mental Disorders Prevalence Tuberculosis Tuberculosis, Multidrug-Resistant Background: The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Therefore, we aimed to quantify the prevalence and types of TB-related disabilities. Methods: We performed a systematic review of TB-related disabilities. The pooled prevalence of disabilities was calculated using the inverse variance heterogeneity model. The maps of the proportions of common types of disabilities by country income level were created. Results: We included a total of 131 studies (217,475 patients) that were conducted in 49 countries. The most common type of disabilities were mental health disorders (23.1%), respiratory impairment (20.7%), musculoskeletal impairment (17.1%), hearing impairment (14.5%), visual impairment (9.8%), renal impairment (5.7%), and neurological impairment (1.6%). The prevalence of respiratory impairment (61.2%) and mental health disorders (42.0%) was highest in low-income countries while neurological impairment was highest in lower middle-income countries (25.6%). Drug-resistant TB was associated with respiratory (58.7%), neurological (37.2%), and hearing impairments (25.0%) and mental health disorders (26.0%), respectively. Conclusions: TB-related disabilities were frequently reported. More uniform reporting tools for TB-related disability and further research to better quantify and mitigate it are urgently needed. Prospero registration number: CRD42019147488 2021 Journal Article http://hdl.handle.net/20.500.11937/86450 10.1186/s12916-021-02063-9 eng http://purl.org/au-research/grants/nhmrc/1121611 http://purl.org/au-research/grants/nhmrc/1107393 http://purl.org/au-research/grants/nhmrc/1196549 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Disability Impairment Meta-analysis Treatment Tuberculosis Disabled Persons Humans Mental Disorders Prevalence Tuberculosis Tuberculosis, Multidrug-Resistant Alene, Kefyalew Wangdi, K. Colquhoun, S. Chani, K. Islam, T. Rahevar, K. Morishita, F. Byrne, A. Clark, J. Viney, K. Tuberculosis related disability: a systematic review and meta-analysis |
| title | Tuberculosis related disability: a systematic review and meta-analysis |
| title_full | Tuberculosis related disability: a systematic review and meta-analysis |
| title_fullStr | Tuberculosis related disability: a systematic review and meta-analysis |
| title_full_unstemmed | Tuberculosis related disability: a systematic review and meta-analysis |
| title_short | Tuberculosis related disability: a systematic review and meta-analysis |
| title_sort | tuberculosis related disability: a systematic review and meta-analysis |
| topic | Disability Impairment Meta-analysis Treatment Tuberculosis Disabled Persons Humans Mental Disorders Prevalence Tuberculosis Tuberculosis, Multidrug-Resistant |
| url | http://purl.org/au-research/grants/nhmrc/1121611 http://purl.org/au-research/grants/nhmrc/1121611 http://purl.org/au-research/grants/nhmrc/1121611 http://hdl.handle.net/20.500.11937/86450 |