Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin
Diabetes mellitus is a chronic metabolic disorder. To improve patient compliance and alleviate the unwanted side effects that are associated with insulin injections, the project aimed to evaluate the potential of nanoparticles in oral delivery of insulin. The developed nanoparticles maintained the b...
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| Format: | Thesis |
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Curtin University
2020
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| Online Access: | http://hdl.handle.net/20.500.11937/85866 |
| _version_ | 1848764774832144384 |
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| author | Wong, Chun Yuen Jerry |
| author_facet | Wong, Chun Yuen Jerry |
| author_sort | Wong, Chun Yuen Jerry |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Diabetes mellitus is a chronic metabolic disorder. To improve patient compliance and alleviate the unwanted side effects that are associated with insulin injections, the project aimed to evaluate the potential of nanoparticles in oral delivery of insulin. The developed nanoparticles maintained the bioactivity of the entrapped insulin, and demonstrated a balance in mucoadhesiveness strength and muco-penetrating capacity. The nanoparticles could preserve the physicochemical properties upon storage, and induce glucose uptake in skeletal muscle cells. |
| first_indexed | 2025-11-14T11:24:42Z |
| format | Thesis |
| id | curtin-20.500.11937-85866 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:24:42Z |
| publishDate | 2020 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-858662021-10-05T05:36:22Z Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin Wong, Chun Yuen Jerry Diabetes mellitus is a chronic metabolic disorder. To improve patient compliance and alleviate the unwanted side effects that are associated with insulin injections, the project aimed to evaluate the potential of nanoparticles in oral delivery of insulin. The developed nanoparticles maintained the bioactivity of the entrapped insulin, and demonstrated a balance in mucoadhesiveness strength and muco-penetrating capacity. The nanoparticles could preserve the physicochemical properties upon storage, and induce glucose uptake in skeletal muscle cells. 2020 Thesis http://hdl.handle.net/20.500.11937/85866 Curtin University fulltext |
| spellingShingle | Wong, Chun Yuen Jerry Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin |
| title | Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin |
| title_full | Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin |
| title_fullStr | Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin |
| title_full_unstemmed | Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin |
| title_short | Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin |
| title_sort | evaluation of chitosan-based nanoparticles in oral delivery of insulin |
| url | http://hdl.handle.net/20.500.11937/85866 |