MCAM in Melanoma Metastasis: The Role of Putative Endocytosis Motifs
Melanoma cell adhesion molecule (MCAM) is a marker of melanoma metastasis and contributes to melanoma progression but how MCAM is sorted and recycled through the cell is unknown. Two putative endocytosis motifs have been identified in the intracellular domain of MCAM. The generation of wild-type and...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/85747 |
| _version_ | 1848764768857358336 |
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| author | Harfield, Jake |
| author_facet | Harfield, Jake |
| author_sort | Harfield, Jake |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Melanoma cell adhesion molecule (MCAM) is a marker of melanoma metastasis and contributes to melanoma progression but how MCAM is sorted and recycled through the cell is unknown. Two putative endocytosis motifs have been identified in the intracellular domain of MCAM. The generation of wild-type and mutant MCAM expressing Colo239F cells was explored in this thesis to determine the role of these endocytosis motifs in melanoma metastasis. |
| first_indexed | 2025-11-14T11:24:37Z |
| format | Thesis |
| id | curtin-20.500.11937-85747 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:24:37Z |
| publishDate | 2021 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-857472023-10-06T03:36:41Z MCAM in Melanoma Metastasis: The Role of Putative Endocytosis Motifs Harfield, Jake Melanoma cell adhesion molecule (MCAM) is a marker of melanoma metastasis and contributes to melanoma progression but how MCAM is sorted and recycled through the cell is unknown. Two putative endocytosis motifs have been identified in the intracellular domain of MCAM. The generation of wild-type and mutant MCAM expressing Colo239F cells was explored in this thesis to determine the role of these endocytosis motifs in melanoma metastasis. 2021 Thesis http://hdl.handle.net/20.500.11937/85747 Curtin University fulltext |
| spellingShingle | Harfield, Jake MCAM in Melanoma Metastasis: The Role of Putative Endocytosis Motifs |
| title | MCAM in Melanoma Metastasis: The Role of
Putative Endocytosis Motifs |
| title_full | MCAM in Melanoma Metastasis: The Role of
Putative Endocytosis Motifs |
| title_fullStr | MCAM in Melanoma Metastasis: The Role of
Putative Endocytosis Motifs |
| title_full_unstemmed | MCAM in Melanoma Metastasis: The Role of
Putative Endocytosis Motifs |
| title_short | MCAM in Melanoma Metastasis: The Role of
Putative Endocytosis Motifs |
| title_sort | mcam in melanoma metastasis: the role of
putative endocytosis motifs |
| url | http://hdl.handle.net/20.500.11937/85747 |