The role of the microtubule manufacturing chaperone TBCD in neuronal
development and brain disorders

QR Code

The role of the microtubule manufacturing chaperone TBCD in neuronal development and brain disorders

Tubulin-specific chaperone D is a microtubule manufacturing chaperone essential to the ability for cells to adopt their appropriate shape, to undergo cell division, as well as to maintain metabolic homeostasis. Recently, homozygous missense mutations to the TBCD gene were reported to cause a severe,...

Full description

Bibliographic Details
Main Author:	Rowlands, Jordan Gareth David
Format:	Thesis
Published:	Curtin University 2021
Online Access:	http://hdl.handle.net/20.500.11937/85546

Similar Items

Alterations in cytoskeletal proteins and microtubule stability following 26S proteasome dysfunction in mouse brain cortical neurons
by: Mohamed, Hala Alhadi Ali
Published: (2017)

Infantile neurodegenerative disorder associated with mutations in TBCD, an essential gene in the tubulin heterodimer assembly pathway
by: Edvardson, S., et al.
Published: (2016)

Studying the role of periplasmic chaperones in Fab presentation on phage surface.
by: Lim , Theam Soon

The Role of Chaperones in Outer Membrane Biogenesis and Host Cell Interactions in Neisseria gonorrhoeae
by: Albalawi, Tawfiq
Published: (2025)

The role of brain signal processing and neuronal modelling in epilepsy – a review
by: Tahereh Najafi,, et al.
Published: (2021)

Dissecting the molecular mechanism of microtubule depolymerising kinesins
by: Belsham, Hannah R.
Published: (2020)

In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones
by: Nur Athirah, Y., et al.
Published: (2015)

Bcp1 is the nuclear chaperone of Rpl23 in Saccharomyces cerevisiae
by: Ting, Ya Han, et al.
Published: (2017)

Vitamin D's role in neuronal development, brain morphology, behaviour, and inflammatory modulation – from a developmental perspective
by: Kozhevnikova, Sofia
Published: (2024)

Additive manufacture of an in vitro neuron biosensor
by: Paul, Benjamin T.
Published: (2019)

Characterisation of a novel microtubule inhibitor and its therapeutic potential
by: Dave, Nikita
Published: (2024)

The effect of obesogenic and inflammatory factors in regulating adipocytes lipid chaperone proteins
by: Mohd Radzuan, Hazulin
Published: (2020)

A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition
by: Belsham, Hannah R., et al.
Published: (2017)

The role of DSPF, the type III secretion chaperone of DspA/E of Erwinia amylovora, in pathogenicity in host and non-host plants
by: Aksoy, Hasan Murad, et al.
Published: (2017)

Magnetic resonance imaging correlates of neuronal degeneration of brain stem nuclei in Parkinson’s disease
by: Schwarz, Stefan Theodor
Published: (2016)

Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons
by: Yates, N., et al.
Published: (2017)

A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue
by: Ellison, Gae, et al.
Published: (2022)

The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition
by: Patel, Jennifer T., et al.
Published: (2016)

Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts
by: Nik, M., et al.
Published: (2014)

Myosin Va’s adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro
by: Oberhofer, Angela, et al.
Published: (2017)

Vibrational analysis of microtubules embedded within viscoelastic medium using orthotropic Kelvin like model
by: Muhammad Safeer,, et al.
Published: (2019)

Chaperone-dependent gene expression of organic solvent-tolerant lipase from Pseudomonas aeruginosa strain S5
by: Baharum, Syarul Nataqain, et al.
Published: (2010)

Neuronal activation in patients with mild and moderate traumatic brain injury during working memory tasks
by: Fitzrol, Diana Noma
Published: (2020)

Role of NMNAT2 regulation in cortical primary neurons
by: Konstantoulaki, Katerina
Published: (2019)

Role of delta-9-tetrahydrocannabinol in neurogenesis and neuronal plast
by: Sulaiman, Noor Azuin
Published: (2013)

Structural modification of Clusianone from Garcinia parvifolia and in vitro evaluation targeting microtubule system of respiratory carcinoma
by: Nagalingam, Sree Vaneesa
Published: (2017)

Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules
by: Yu, Yu, et al.
Published: (2015)

The Involvement of Microtubules and Actin during the Infection of Japanese Encephalitis Virus in Neuroblastoma Cell Line, IMR32
by: Magdline Sia, Henry Sum
Published: (2014)

The Involvement of Microtubules and Actin during the Infection of Japanese Encephalitis Virus in Neuroblastoma Cell Line, IMR32
by: Henry Sum, Magdline Sia
Published: (2015)

Brain Changes in Iron Loading Disorders
by: Milward, E., et al.
Published: (2012)

Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27
by: Mellier, G., et al.
Published: (2013)

The RNA chaperone, Hfq, controls two luxR-type regulators and plays a key role in pathogenesis and production of antibiotics in Serratia sp. ATCC 39006
by: Wilf, N., et al.
Published: (2011)

MyosinVa and dynamic actin oppose minus-end directed microtubule motors to drive anterograde melanosome transport
by: Robinson, Christopher L.
Published: (2016)

Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system
by: Beaven, Robin, et al.
Published: (2015)

Analysis of shared heritability in common disorders of the brain
by: Anttila, Verneri, et al.
Published: (2018)

Brain Waves and Connectivity of Autism Spectrum Disorders
by: Norsiah, Fauzan, et al.
Published: (2015)

Simulation Of Oscillations In Neuronal Networks Using The Morris-Lecar Neuron Model
by: Cheng, Chan Siow
Published: (2015)

Evaluation of neuroprotective effects of tualang honey on paraquat-induced oxidative stress & dopaminergic neuron damage in the rat brain
by: Sulaiman, Siti Amrah
Published: (2016)

Neuron-immune mechanisms contribute to pain in early stages of arthritis
by: Nieto, Francisco R., et al.
Published: (2016)

Mirror neuron system activation in children with developmental coordination disorder: A replication functional MRI study
by: Reynolds, J., et al.
Published: (2019)