The role of the microtubule manufacturing chaperone TBCD in neuronal development and brain disorders
Tubulin-specific chaperone D is a microtubule manufacturing chaperone essential to the ability for cells to adopt their appropriate shape, to undergo cell division, as well as to maintain metabolic homeostasis. Recently, homozygous missense mutations to the TBCD gene were reported to cause a severe,...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/85546 |
| _version_ | 1848764742400737280 |
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| author | Rowlands, Jordan Gareth David |
| author_facet | Rowlands, Jordan Gareth David |
| author_sort | Rowlands, Jordan Gareth David |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Tubulin-specific chaperone D is a microtubule manufacturing chaperone essential to the ability for cells to adopt their appropriate shape, to undergo cell division, as well as to maintain metabolic homeostasis. Recently, homozygous missense mutations to the TBCD gene were reported to cause a severe, early onset neurodegenerative condition in infants. This thesis illuminates the vast and interconnected molecular mechanisms through which TBCD and its clinically-relevant mutations influence cell cycle, metabolism and differentiation. |
| first_indexed | 2025-11-14T11:24:11Z |
| format | Thesis |
| id | curtin-20.500.11937-85546 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:24:11Z |
| publishDate | 2021 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-855462021-09-13T06:46:02Z The role of the microtubule manufacturing chaperone TBCD in neuronal development and brain disorders Rowlands, Jordan Gareth David Tubulin-specific chaperone D is a microtubule manufacturing chaperone essential to the ability for cells to adopt their appropriate shape, to undergo cell division, as well as to maintain metabolic homeostasis. Recently, homozygous missense mutations to the TBCD gene were reported to cause a severe, early onset neurodegenerative condition in infants. This thesis illuminates the vast and interconnected molecular mechanisms through which TBCD and its clinically-relevant mutations influence cell cycle, metabolism and differentiation. 2021 Thesis http://hdl.handle.net/20.500.11937/85546 Curtin University fulltext |
| spellingShingle | Rowlands, Jordan Gareth David The role of the microtubule manufacturing chaperone TBCD in neuronal development and brain disorders |
| title | The role of the microtubule manufacturing chaperone TBCD in neuronal
development and brain disorders |
| title_full | The role of the microtubule manufacturing chaperone TBCD in neuronal
development and brain disorders |
| title_fullStr | The role of the microtubule manufacturing chaperone TBCD in neuronal
development and brain disorders |
| title_full_unstemmed | The role of the microtubule manufacturing chaperone TBCD in neuronal
development and brain disorders |
| title_short | The role of the microtubule manufacturing chaperone TBCD in neuronal
development and brain disorders |
| title_sort | role of the microtubule manufacturing chaperone tbcd in neuronal
development and brain disorders |
| url | http://hdl.handle.net/20.500.11937/85546 |