In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties
An opaque, white chitosan/ Hydroxyapatite nanocomposite was prepared by a simple blend method. Morphology, pore size and dispersion of nano-hydroxyapatite in chitosan matrix were visualized using SEM images. The FTIR and SEM with EDX analysis confirmed the bony apatite layer was formed on the outsid...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/85012 |
| _version_ | 1848764710011273216 |
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| author | Lipton, Anuj Nishanth Fathima, A. Vincent, S. |
| author_facet | Lipton, Anuj Nishanth Fathima, A. Vincent, S. |
| author_sort | Lipton, Anuj Nishanth |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | An opaque, white chitosan/ Hydroxyapatite nanocomposite was prepared by a simple blend method. Morphology, pore size and dispersion of nano-hydroxyapatite in chitosan matrix were visualized using SEM images. The FTIR and SEM with EDX analysis confirmed the bony apatite layer was formed on the outside of the composite. Porosity measurements and water uptake studies of the nanocomposite were evaluated which revealed the maximum porosity of 80% to 92% in the chitosan: hydroxyapatite nanocomposite at the ratio of 20:80. The results also showed that water absorption ability was inversely proportional to the hydroxyapatite present in the nanocomposite. The porosity of prepared nanocomposite was corresponding to the cancellous bone porosity of 50% to 90% suggesting possible applications in bone transplantation. The nanocomposite exhibited antibacterial activity towards the tested Gram-negative and Gram-positive species of bacteria and reduced the bacterial adhesion in biofilm formation. |
| first_indexed | 2025-11-14T11:23:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-85012 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:23:40Z |
| publishDate | 2021 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-850122021-11-05T05:10:42Z In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties Lipton, Anuj Nishanth Fathima, A. Vincent, S. An opaque, white chitosan/ Hydroxyapatite nanocomposite was prepared by a simple blend method. Morphology, pore size and dispersion of nano-hydroxyapatite in chitosan matrix were visualized using SEM images. The FTIR and SEM with EDX analysis confirmed the bony apatite layer was formed on the outside of the composite. Porosity measurements and water uptake studies of the nanocomposite were evaluated which revealed the maximum porosity of 80% to 92% in the chitosan: hydroxyapatite nanocomposite at the ratio of 20:80. The results also showed that water absorption ability was inversely proportional to the hydroxyapatite present in the nanocomposite. The porosity of prepared nanocomposite was corresponding to the cancellous bone porosity of 50% to 90% suggesting possible applications in bone transplantation. The nanocomposite exhibited antibacterial activity towards the tested Gram-negative and Gram-positive species of bacteria and reduced the bacterial adhesion in biofilm formation. 2021 Journal Article http://hdl.handle.net/20.500.11937/85012 10.22207/JPAM.15.3.39 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Lipton, Anuj Nishanth Fathima, A. Vincent, S. In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties |
| title | In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties |
| title_full | In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties |
| title_fullStr | In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties |
| title_full_unstemmed | In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties |
| title_short | In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties |
| title_sort | in-vitro evaluation of chitosan - hydroxyapatite nanocomposite scaffolds as bone substitutes with antibiofilm properties |
| url | http://hdl.handle.net/20.500.11937/85012 |