Carbon dioxide laser treatment in burn-related scarring: A prospective randomised controlled trial
Aim: To investigate the effect of ablative fractional CO2 laser (AFCO2L) on burns scar appearance and dermal architecture at 6 weeks and up to 3-years post-treatment. Methods: Twenty adult patients with a burn-related scar were recruited. Inclusion criteria were a minimum scar area of 10 × 10 cm...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/84886 |
| _version_ | 1848764697496518656 |
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| author | Douglas, H. Lynch, J. Harms, K.A. Krop, T. Kunath, L. van Vreeswijk, C. McGarry, Sarah Fear, M.W. Wood, F.M. Murray, A. Rea, S. |
| author_facet | Douglas, H. Lynch, J. Harms, K.A. Krop, T. Kunath, L. van Vreeswijk, C. McGarry, Sarah Fear, M.W. Wood, F.M. Murray, A. Rea, S. |
| author_sort | Douglas, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Aim: To investigate the effect of ablative fractional CO2 laser (AFCO2L) on burns scar appearance and dermal architecture at 6 weeks and up to 3-years post-treatment.
Methods: Twenty adult patients with a burn-related scar were recruited. Inclusion criteria were a minimum scar area of 10 × 10 cm and Vancouver scar scale (VSS) score of >5 and ≥6 months since the time of injury. The region of scar was randomised to treatment/control zones. Treatment zones received 3 standardised laser treatments at 4- to 6-week intervals. All areas of scar received standard scar care. Outcome measures were recorded at baseline, 6-weeks post final treatment and up to 3 years post-treatment. Measures included blinded assessor VSS, Patient Scar Assessment Scale and histological tissue analysis.
Results: Nineteen and nine patients completed the short- and long-term studies, respectively. Clinical results revealed improvement in all scar areas over time. There was a statistically significant improvement in pain and itch in the treatment zone compared to the control zone at 6 weeks. Histological data revealed a significant increase in medium-sized collagen fibres at 6 weeks relative to the control site. Sub-group analysis according to scar age revealed greater histological improvement following laser treatment in immature scars relative to more mature scar.
Conclusions: Results demonstrate that 3 treatments of AFCO2L significantly improve scar pain, itch and dermal architecture at 6 weeks post-treatment. Histological results suggest greater potential in treating immature scar. Further investigation into the timing of laser treatment could help assist treatment protocols. |
| first_indexed | 2025-11-14T11:23:29Z |
| format | Journal Article |
| id | curtin-20.500.11937-84886 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:23:29Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-848862021-09-16T03:22:36Z Carbon dioxide laser treatment in burn-related scarring: A prospective randomised controlled trial Douglas, H. Lynch, J. Harms, K.A. Krop, T. Kunath, L. van Vreeswijk, C. McGarry, Sarah Fear, M.W. Wood, F.M. Murray, A. Rea, S. Ablative fractional laser Burn CO(2) laser Scar Adult Burns Cicatrix Female Humans Lasers, Gas Male Middle Aged Pain Measurement Pruritus Reconstructive Surgical Procedures Skin Time-to-Treatment Treatment Outcome Aim: To investigate the effect of ablative fractional CO2 laser (AFCO2L) on burns scar appearance and dermal architecture at 6 weeks and up to 3-years post-treatment. Methods: Twenty adult patients with a burn-related scar were recruited. Inclusion criteria were a minimum scar area of 10 × 10 cm and Vancouver scar scale (VSS) score of >5 and ≥6 months since the time of injury. The region of scar was randomised to treatment/control zones. Treatment zones received 3 standardised laser treatments at 4- to 6-week intervals. All areas of scar received standard scar care. Outcome measures were recorded at baseline, 6-weeks post final treatment and up to 3 years post-treatment. Measures included blinded assessor VSS, Patient Scar Assessment Scale and histological tissue analysis. Results: Nineteen and nine patients completed the short- and long-term studies, respectively. Clinical results revealed improvement in all scar areas over time. There was a statistically significant improvement in pain and itch in the treatment zone compared to the control zone at 6 weeks. Histological data revealed a significant increase in medium-sized collagen fibres at 6 weeks relative to the control site. Sub-group analysis according to scar age revealed greater histological improvement following laser treatment in immature scars relative to more mature scar. Conclusions: Results demonstrate that 3 treatments of AFCO2L significantly improve scar pain, itch and dermal architecture at 6 weeks post-treatment. Histological results suggest greater potential in treating immature scar. Further investigation into the timing of laser treatment could help assist treatment protocols. 2019 Journal Article http://hdl.handle.net/20.500.11937/84886 10.1016/j.bjps.2019.01.027 eng restricted |
| spellingShingle | Ablative fractional laser Burn CO(2) laser Scar Adult Burns Cicatrix Female Humans Lasers, Gas Male Middle Aged Pain Measurement Pruritus Reconstructive Surgical Procedures Skin Time-to-Treatment Treatment Outcome Douglas, H. Lynch, J. Harms, K.A. Krop, T. Kunath, L. van Vreeswijk, C. McGarry, Sarah Fear, M.W. Wood, F.M. Murray, A. Rea, S. Carbon dioxide laser treatment in burn-related scarring: A prospective randomised controlled trial |
| title | Carbon dioxide laser treatment in burn-related scarring: A prospective randomised controlled trial |
| title_full | Carbon dioxide laser treatment in burn-related scarring: A prospective randomised controlled trial |
| title_fullStr | Carbon dioxide laser treatment in burn-related scarring: A prospective randomised controlled trial |
| title_full_unstemmed | Carbon dioxide laser treatment in burn-related scarring: A prospective randomised controlled trial |
| title_short | Carbon dioxide laser treatment in burn-related scarring: A prospective randomised controlled trial |
| title_sort | carbon dioxide laser treatment in burn-related scarring: a prospective randomised controlled trial |
| topic | Ablative fractional laser Burn CO(2) laser Scar Adult Burns Cicatrix Female Humans Lasers, Gas Male Middle Aged Pain Measurement Pruritus Reconstructive Surgical Procedures Skin Time-to-Treatment Treatment Outcome |
| url | http://hdl.handle.net/20.500.11937/84886 |