Brainstem functional oscillations across the migraine cycle: A longitudinal investigation
Although the mechanisms responsible for migraine initiation remain unknown, recent evidence shows that brain function is different immediately preceding a migraine. This is consistent with the idea that altered brain function, particularly in brainstem sites, may either trigger a migraine or facilit...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1032072 http://hdl.handle.net/20.500.11937/84865 |
| _version_ | 1848764696308482048 |
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| author | Meylakh, N. Marciszewski, K.K. Di Pietro, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. |
| author_facet | Meylakh, N. Marciszewski, K.K. Di Pietro, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. |
| author_sort | Meylakh, N. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Although the mechanisms responsible for migraine initiation remain unknown, recent evidence shows that brain function is different immediately preceding a migraine. This is consistent with the idea that altered brain function, particularly in brainstem sites, may either trigger a migraine or facilitate a peripheral trigger that activates the brain, resulting in pain. The aim of this longitudinal study is therefore to expand on the above findings, and to determine if brainstem function oscillates over a migraine cycle in individual subjects. We performed resting state functional magnetic resonance imaging in three migraineurs and five controls each weekday for four weeks. We found that although resting activity variability was similar in controls and interictal migraineurs, brainstem variability increased dramatically during the 24-hour period preceding a migraine. This increase occurred in brainstem areas in which orofacial afferents terminate: the spinal trigeminal nucleus and dorsal pons. These increases were characterized by increased power at infra-slow frequencies, principally between 0.03 and 0.06 Hz. Furthermore, these power increases were associated with increased regional homogeneity, a measure of local signal coherence. The results show within-individual alterations in brain activity immediately preceding migraine onset and support the hypothesis that altered regional brainstem function before a migraine attack is involved in underlying migraine neurobiology. |
| first_indexed | 2025-11-14T11:23:27Z |
| format | Journal Article |
| id | curtin-20.500.11937-84865 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:23:27Z |
| publishDate | 2021 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-848652021-08-13T05:01:00Z Brainstem functional oscillations across the migraine cycle: A longitudinal investigation Meylakh, N. Marciszewski, K.K. Di Pietro, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. Astrocytes Dorsal pons Infra-slow oscillations Resting state functional magnetic resonance imaging Spinal trigeminal nucleus Although the mechanisms responsible for migraine initiation remain unknown, recent evidence shows that brain function is different immediately preceding a migraine. This is consistent with the idea that altered brain function, particularly in brainstem sites, may either trigger a migraine or facilitate a peripheral trigger that activates the brain, resulting in pain. The aim of this longitudinal study is therefore to expand on the above findings, and to determine if brainstem function oscillates over a migraine cycle in individual subjects. We performed resting state functional magnetic resonance imaging in three migraineurs and five controls each weekday for four weeks. We found that although resting activity variability was similar in controls and interictal migraineurs, brainstem variability increased dramatically during the 24-hour period preceding a migraine. This increase occurred in brainstem areas in which orofacial afferents terminate: the spinal trigeminal nucleus and dorsal pons. These increases were characterized by increased power at infra-slow frequencies, principally between 0.03 and 0.06 Hz. Furthermore, these power increases were associated with increased regional homogeneity, a measure of local signal coherence. The results show within-individual alterations in brain activity immediately preceding migraine onset and support the hypothesis that altered regional brainstem function before a migraine attack is involved in underlying migraine neurobiology. 2021 Journal Article http://hdl.handle.net/20.500.11937/84865 10.1016/j.nicl.2021.102630 eng http://purl.org/au-research/grants/nhmrc/1032072 http://purl.org/au-research/grants/nhmrc/1059182 http://creativecommons.org/licenses/by-nc-nd/4.0/ fulltext |
| spellingShingle | Astrocytes Dorsal pons Infra-slow oscillations Resting state functional magnetic resonance imaging Spinal trigeminal nucleus Meylakh, N. Marciszewski, K.K. Di Pietro, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. Brainstem functional oscillations across the migraine cycle: A longitudinal investigation |
| title | Brainstem functional oscillations across the migraine cycle: A longitudinal investigation |
| title_full | Brainstem functional oscillations across the migraine cycle: A longitudinal investigation |
| title_fullStr | Brainstem functional oscillations across the migraine cycle: A longitudinal investigation |
| title_full_unstemmed | Brainstem functional oscillations across the migraine cycle: A longitudinal investigation |
| title_short | Brainstem functional oscillations across the migraine cycle: A longitudinal investigation |
| title_sort | brainstem functional oscillations across the migraine cycle: a longitudinal investigation |
| topic | Astrocytes Dorsal pons Infra-slow oscillations Resting state functional magnetic resonance imaging Spinal trigeminal nucleus |
| url | http://purl.org/au-research/grants/nhmrc/1032072 http://purl.org/au-research/grants/nhmrc/1032072 http://hdl.handle.net/20.500.11937/84865 |