The role of G protein-coupled receptor 35 in pancreatic cancer
This PhD thesis discusses the novel therapeutic target of PDAC, which is GPR35. For the first time, we have characterized its diverse roles controlling apoptosis, autophagy, cell cycle arrests, migration and invasion in PDAC cells. In addition, this work provides its related signalling pathways whic...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2020
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| Online Access: | http://hdl.handle.net/20.500.11937/84527 |
| _version_ | 1848764656157458432 |
|---|---|
| author | Kim, Minkyoung |
| author_facet | Kim, Minkyoung |
| author_sort | Kim, Minkyoung |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This PhD thesis discusses the novel therapeutic target of PDAC, which is GPR35. For the first time, we have characterized its diverse roles controlling apoptosis, autophagy, cell cycle arrests, migration and invasion in PDAC cells. In addition, this work provides its related signalling pathways which are AKT and HIF-1. Our investigation of GPR35 in PDAC has contributed to suggest a new therapeutic strategy to cure pancreatic cancer patients. |
| first_indexed | 2025-11-14T11:22:49Z |
| format | Thesis |
| id | curtin-20.500.11937-84527 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:22:49Z |
| publishDate | 2020 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-845272021-07-14T05:39:08Z The role of G protein-coupled receptor 35 in pancreatic cancer Kim, Minkyoung This PhD thesis discusses the novel therapeutic target of PDAC, which is GPR35. For the first time, we have characterized its diverse roles controlling apoptosis, autophagy, cell cycle arrests, migration and invasion in PDAC cells. In addition, this work provides its related signalling pathways which are AKT and HIF-1. Our investigation of GPR35 in PDAC has contributed to suggest a new therapeutic strategy to cure pancreatic cancer patients. 2020 Thesis http://hdl.handle.net/20.500.11937/84527 Curtin University fulltext |
| spellingShingle | Kim, Minkyoung The role of G protein-coupled receptor 35 in pancreatic cancer |
| title | The role of G protein-coupled receptor 35 in pancreatic cancer |
| title_full | The role of G protein-coupled receptor 35 in pancreatic cancer |
| title_fullStr | The role of G protein-coupled receptor 35 in pancreatic cancer |
| title_full_unstemmed | The role of G protein-coupled receptor 35 in pancreatic cancer |
| title_short | The role of G protein-coupled receptor 35 in pancreatic cancer |
| title_sort | role of g protein-coupled receptor 35 in pancreatic cancer |
| url | http://hdl.handle.net/20.500.11937/84527 |