Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy
The goal of this research was to develop in vitro mesothelioma models representing normoxic (20% O2) or hypoxic (2% O2) environments (likely representing a large mesothelioma tumour), to study the crosstalk between mesothelioma cells, tumour-associated macrophages and endothelial cells. The models w...
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| Format: | Thesis |
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Curtin University
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/84211 |
| _version_ | 1848764624450617344 |
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| author | Alrehaily, Abdulwahed |
| author_facet | Alrehaily, Abdulwahed |
| author_sort | Alrehaily, Abdulwahed |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The goal of this research was to develop in vitro mesothelioma models representing normoxic (20% O2) or hypoxic (2% O2) environments (likely representing a large mesothelioma tumour), to study the crosstalk between mesothelioma cells, tumour-associated macrophages and endothelial cells. The models were used to study the effect of immunotherapies involving interleukin-2 and anti-CD40 antibody on these cells’ relationships. The data show that hypoxia influences the function of these cells and their responses to immunotherapies. |
| first_indexed | 2025-11-14T11:22:19Z |
| format | Thesis |
| id | curtin-20.500.11937-84211 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:22:19Z |
| publishDate | 2021 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-842112021-07-01T07:00:40Z Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy Alrehaily, Abdulwahed The goal of this research was to develop in vitro mesothelioma models representing normoxic (20% O2) or hypoxic (2% O2) environments (likely representing a large mesothelioma tumour), to study the crosstalk between mesothelioma cells, tumour-associated macrophages and endothelial cells. The models were used to study the effect of immunotherapies involving interleukin-2 and anti-CD40 antibody on these cells’ relationships. The data show that hypoxia influences the function of these cells and their responses to immunotherapies. 2021 Thesis http://hdl.handle.net/20.500.11937/84211 Curtin University fulltext |
| spellingShingle | Alrehaily, Abdulwahed Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy |
| title | Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy |
| title_full | Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy |
| title_fullStr | Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy |
| title_full_unstemmed | Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy |
| title_short | Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy |
| title_sort | hypoxic regions in mesothelioma likely modulate cross-talk between tumour cells, macrophages and endothelial cells and regulate responses to immunotherapy |
| url | http://hdl.handle.net/20.500.11937/84211 |