Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy
The goal of this research was to develop in vitro mesothelioma models representing normoxic (20% O2) or hypoxic (2% O2) environments (likely representing a large mesothelioma tumour), to study the crosstalk between mesothelioma cells, tumour-associated macrophages and endothelial cells. The models w...
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| Format: | Thesis |
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Curtin University
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/84211 |
| Summary: | The goal of this research was to develop in vitro mesothelioma models representing normoxic (20% O2) or hypoxic (2% O2) environments (likely representing a large mesothelioma tumour), to study the crosstalk between mesothelioma cells, tumour-associated macrophages and endothelial cells. The models were used to study the effect of immunotherapies involving interleukin-2 and anti-CD40 antibody on these cells’ relationships. The data show that hypoxia influences the function of these cells and their responses to immunotherapies. |
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