A phosphorylation-induced turn defines the Alzheimer's disease AT8 antibody epitope on the tau protein

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A phosphorylation-induced turn defines the Alzheimer's disease AT8 antibody epitope on the tau protein

Post mortem biochemical staging of Alzheimer’s disease is currently based on immunochemical analysis of brain slices with the AT8 antibody. The epitope of AT8 is described around the pSer202/pThr205 region of the hyperphosphorylated form of the neuronal protein tau. In this study, NMR spectroscopy w...

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Bibliographic Details
Main Authors:	Gandhi, Neha, Landrieu, I., Byrne, C., Kukic, P., Amniai, L., Cantrelle, F., Wieruszeski, J., Mancera, Ricardo, Jacquot, Y., Lippens, G.
Format:	Journal Article
Published:	Wiley-VCH Verlag 2015
Online Access:	http://hdl.handle.net/20.500.11937/8408

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