Autoantibody-catalyzed hydrolysis of amyloid ß peptide

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Autoantibody-catalyzed hydrolysis of amyloid ß peptide

We describe IgM class human autoantibodies that hydrolyze amyloid ß peptide 1-40 (Aß40). A monoclonal IgM from a patient with Waldenström's macroglobulinemia hydrolyzed Aß40 at the Lys-28 - Gly-29 bond and Lys-16 - Ala-17 bonds. The catalytic activity was inhibited stoichiometrically by an elec...

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Bibliographic Details
Main Authors:	Taguchi, H., Planque, S., Nishiyama, Y., Symersky, J., Boivin, S., Szabo, P., Friedland, R., Ramsland, Paul, Edmundson, A., Weksler, M., Paul, S.
Format:	Journal Article
Published:	The American Society for Biochemistry and Molecular Biology Inc 2008
Online Access:	http://hdl.handle.net/20.500.11937/8339

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