Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches.
There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed...
| Main Authors: | , , |
|---|---|
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/82630 |
| _version_ | 1848764525619183616 |
|---|---|
| author | Elnashar, Magdy Vaccarezza, Mauro Al-Salami, Hani |
| author_facet | Elnashar, Magdy Vaccarezza, Mauro Al-Salami, Hani |
| author_sort | Elnashar, Magdy |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids. |
| first_indexed | 2025-11-14T11:20:45Z |
| format | Journal Article |
| id | curtin-20.500.11937-82630 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:20:45Z |
| publishDate | 2020 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-826302021-03-11T05:12:51Z Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. Elnashar, Magdy Vaccarezza, Mauro Al-Salami, Hani Type 1 diabetes auto-transplantation bile acid diabetes treatment encapsulation human pancreas pancreatic islets stem cells transplantation There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids. 2020 Journal Article http://hdl.handle.net/20.500.11937/82630 10.2144/fsoa-2020-0105 eng http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Type 1 diabetes auto-transplantation bile acid diabetes treatment encapsulation human pancreas pancreatic islets stem cells transplantation Elnashar, Magdy Vaccarezza, Mauro Al-Salami, Hani Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. |
| title | Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. |
| title_full | Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. |
| title_fullStr | Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. |
| title_full_unstemmed | Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. |
| title_short | Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. |
| title_sort | cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. |
| topic | Type 1 diabetes auto-transplantation bile acid diabetes treatment encapsulation human pancreas pancreatic islets stem cells transplantation |
| url | http://hdl.handle.net/20.500.11937/82630 |