The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49
Recent evidence has investigated the costeffectiveness of magnetic resonance imaging (MRI) in younger women with a BRCA1 mutation. However, this evidence has not been contrasted with existing cost-effectiveness standards to determine whether screening is appropriate, given limited societal resourc...
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| Format: | Journal Article |
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Springer
2007
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| Online Access: | http://www.springer.com/economics/policy/journal/10198 http://hdl.handle.net/20.500.11937/8246 |
| _version_ | 1848745598759469056 |
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| author | Norman, Richard Evans, D. Easton, D. Young, K. |
| author_facet | Norman, Richard Evans, D. Easton, D. Young, K. |
| author_sort | Norman, Richard |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Recent evidence has investigated the costeffectiveness of magnetic resonance imaging (MRI) in younger women with a BRCA1 mutation. However, this evidence has not been contrasted with existing cost-effectiveness standards to determine whether screening is appropriate, given limited societal resources. We constructed a Markov model investigating surveillance tools (mammography, MRI, both in parallel) under a National Health Service (NHS) perspective. The key benefit of MRI is that increased sensitivity leads to early detection, and improved prognosis. For a 30- to 39-year-old cohort, the cost per quality-adjusted life year (QALY) of mammography relative to no screening was £5,200. The addition of MRI to this costs £13,486 per QALY. For a 40- to 49-year-old cohort, the corresponding values were £2,913 and £7,781. Probabilistic sensitivity analysis supported the cost-effectiveness of the parallel approach of mammography and MRI. It is necessary to extend this analysis beyond BRCA1 carriers within this age group, and also to other age groups. |
| first_indexed | 2025-11-14T06:19:55Z |
| format | Journal Article |
| id | curtin-20.500.11937-8246 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:19:55Z |
| publishDate | 2007 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-82462017-09-13T14:37:00Z The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49 Norman, Richard Evans, D. Easton, D. Young, K. Cost-utility Mammography MRI Surveillance BRCA1 Recent evidence has investigated the costeffectiveness of magnetic resonance imaging (MRI) in younger women with a BRCA1 mutation. However, this evidence has not been contrasted with existing cost-effectiveness standards to determine whether screening is appropriate, given limited societal resources. We constructed a Markov model investigating surveillance tools (mammography, MRI, both in parallel) under a National Health Service (NHS) perspective. The key benefit of MRI is that increased sensitivity leads to early detection, and improved prognosis. For a 30- to 39-year-old cohort, the cost per quality-adjusted life year (QALY) of mammography relative to no screening was £5,200. The addition of MRI to this costs £13,486 per QALY. For a 40- to 49-year-old cohort, the corresponding values were £2,913 and £7,781. Probabilistic sensitivity analysis supported the cost-effectiveness of the parallel approach of mammography and MRI. It is necessary to extend this analysis beyond BRCA1 carriers within this age group, and also to other age groups. 2007 Journal Article http://hdl.handle.net/20.500.11937/8246 10.1007/s10198-007-0042-9 http://www.springer.com/economics/policy/journal/10198 Springer restricted |
| spellingShingle | Cost-utility Mammography MRI Surveillance BRCA1 Norman, Richard Evans, D. Easton, D. Young, K. The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49 |
| title | The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49 |
| title_full | The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49 |
| title_fullStr | The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49 |
| title_full_unstemmed | The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49 |
| title_short | The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49 |
| title_sort | cost-utility of magnetic resonance imaging for breast cancer in brca1 mutation carriers aged 30–49 |
| topic | Cost-utility Mammography MRI Surveillance BRCA1 |
| url | http://www.springer.com/economics/policy/journal/10198 http://hdl.handle.net/20.500.11937/8246 |