Maternal Medication Use and the Risk to Breastfed Infants: A Focus on Active Efflux Transporters and Changes in Expression During the Course of Lactation
This thesis has highlighted the role of BCRP as a potential significant mediator of drug movement from mother to baby through breastmilk. However, it was also shown that only epithelial cells collected from breastmilk represent expression of efflux proteins but the same cells propagated in culture l...
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| Format: | Thesis |
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Curtin University
2020
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| Online Access: | http://hdl.handle.net/20.500.11937/82266 |
| _version_ | 1848764490054631424 |
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| author | Ahmadzai, Hilai |
| author_facet | Ahmadzai, Hilai |
| author_sort | Ahmadzai, Hilai |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis has highlighted the role of BCRP as a potential significant mediator of drug movement from mother to baby through breastmilk. However, it was also shown that only epithelial cells collected from breastmilk represent expression of efflux proteins but the same cells propagated in culture lose their in-vivo characteristics. The need for better lactation related medication safety data and pharmacovigilance was also highlighted as infant ADRs attributed to breastfeeding were shown to be underreported. |
| first_indexed | 2025-11-14T11:20:11Z |
| format | Thesis |
| id | curtin-20.500.11937-82266 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:20:11Z |
| publishDate | 2020 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-822662022-12-15T06:31:47Z Maternal Medication Use and the Risk to Breastfed Infants: A Focus on Active Efflux Transporters and Changes in Expression During the Course of Lactation Ahmadzai, Hilai This thesis has highlighted the role of BCRP as a potential significant mediator of drug movement from mother to baby through breastmilk. However, it was also shown that only epithelial cells collected from breastmilk represent expression of efflux proteins but the same cells propagated in culture lose their in-vivo characteristics. The need for better lactation related medication safety data and pharmacovigilance was also highlighted as infant ADRs attributed to breastfeeding were shown to be underreported. 2020 Thesis http://hdl.handle.net/20.500.11937/82266 Curtin University fulltext |
| spellingShingle | Ahmadzai, Hilai Maternal Medication Use and the Risk to Breastfed Infants: A Focus on Active Efflux Transporters and Changes in Expression During the Course of Lactation |
| title | Maternal Medication Use and the Risk to Breastfed Infants: A Focus on Active Efflux Transporters and Changes in Expression During the Course of Lactation |
| title_full | Maternal Medication Use and the Risk to Breastfed Infants: A Focus on Active Efflux Transporters and Changes in Expression During the Course of Lactation |
| title_fullStr | Maternal Medication Use and the Risk to Breastfed Infants: A Focus on Active Efflux Transporters and Changes in Expression During the Course of Lactation |
| title_full_unstemmed | Maternal Medication Use and the Risk to Breastfed Infants: A Focus on Active Efflux Transporters and Changes in Expression During the Course of Lactation |
| title_short | Maternal Medication Use and the Risk to Breastfed Infants: A Focus on Active Efflux Transporters and Changes in Expression During the Course of Lactation |
| title_sort | maternal medication use and the risk to breastfed infants: a focus on active efflux transporters and changes in expression during the course of lactation |
| url | http://hdl.handle.net/20.500.11937/82266 |