Role of vitamin D metabolism in cutaneous tumour formation and progression
Objectives: Very limited information is available on the role of vitamin D in skin carcinogenesis. For most individuals, skin cancer can be readily managed with surgery; however, some patients may face life-threatening neoplasia. Sun exposure, specifically UV radiation, is a causative agent for dev...
| Main Authors: | , , |
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| Format: | Journal Article |
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John Wiley & Sons Ltd.
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/8215 |
| _version_ | 1848745589766881280 |
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| author | Nemazannikova, N. Antonas, K. Dass, Crispin |
| author_facet | Nemazannikova, N. Antonas, K. Dass, Crispin |
| author_sort | Nemazannikova, N. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: Very limited information is available on the role of vitamin D in skin carcinogenesis. For most individuals, skin cancer can be readily managed with surgery; however, some patients may face life-threatening neoplasia. Sun exposure, specifically UV radiation, is a causative agent for development of skin cancer, though, somewhat ironically, sunlight through the production of vitamin D may have protective effect against some skin cancers. This review focuses on the development and progression of cutaneous carcinogenesis and the role of vitamin D in the prevention of the initiation and progression of lethal skin cancers.Key findings: Vitamin D is involved in regulation of multiple signalling pathways that have implications in carcinogenesis. Skin cancer metastasis depends on the tumour microenvironment, where vitamin D metabolites play a key role in prevention of certain molecular events involved in tumour progression. The vitamin D receptor (VDR) is a well-known potent regulator of cellular growth and differentiation.Summary: The VDR's possible involvement in cell death, tumour microenvironment and angiogenesis makes it a candidate agent for cancer regulation. |
| first_indexed | 2025-11-14T06:19:46Z |
| format | Journal Article |
| id | curtin-20.500.11937-8215 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:19:46Z |
| publishDate | 2013 |
| publisher | John Wiley & Sons Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-82152017-09-13T15:54:28Z Role of vitamin D metabolism in cutaneous tumour formation and progression Nemazannikova, N. Antonas, K. Dass, Crispin skin cancer dermal fibroblast vitamin D Objectives: Very limited information is available on the role of vitamin D in skin carcinogenesis. For most individuals, skin cancer can be readily managed with surgery; however, some patients may face life-threatening neoplasia. Sun exposure, specifically UV radiation, is a causative agent for development of skin cancer, though, somewhat ironically, sunlight through the production of vitamin D may have protective effect against some skin cancers. This review focuses on the development and progression of cutaneous carcinogenesis and the role of vitamin D in the prevention of the initiation and progression of lethal skin cancers.Key findings: Vitamin D is involved in regulation of multiple signalling pathways that have implications in carcinogenesis. Skin cancer metastasis depends on the tumour microenvironment, where vitamin D metabolites play a key role in prevention of certain molecular events involved in tumour progression. The vitamin D receptor (VDR) is a well-known potent regulator of cellular growth and differentiation.Summary: The VDR's possible involvement in cell death, tumour microenvironment and angiogenesis makes it a candidate agent for cancer regulation. 2013 Journal Article http://hdl.handle.net/20.500.11937/8215 10.1111/j.2042-7158.2012.01527.x John Wiley & Sons Ltd. unknown |
| spellingShingle | skin cancer dermal fibroblast vitamin D Nemazannikova, N. Antonas, K. Dass, Crispin Role of vitamin D metabolism in cutaneous tumour formation and progression |
| title | Role of vitamin D metabolism in cutaneous tumour formation and progression |
| title_full | Role of vitamin D metabolism in cutaneous tumour formation and progression |
| title_fullStr | Role of vitamin D metabolism in cutaneous tumour formation and progression |
| title_full_unstemmed | Role of vitamin D metabolism in cutaneous tumour formation and progression |
| title_short | Role of vitamin D metabolism in cutaneous tumour formation and progression |
| title_sort | role of vitamin d metabolism in cutaneous tumour formation and progression |
| topic | skin cancer dermal fibroblast vitamin D |
| url | http://hdl.handle.net/20.500.11937/8215 |