Long-term survival following laparoscopic and open colectomy for colon cancer: a meta-analysis of randomized controlled trials
Aim: Large randomized clinical trials comparing long-term survival after laparoscopic and open colectomy for large bowel cancer show equivalence, but meaningful analysis of data by stage has not been possible due to the small numbers of patients in individual trials. The aim of this meta-analysis wa...
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| Format: | Journal Article |
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Wiley
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/8204 |
| _version_ | 1848745586662047744 |
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| author | Theophilus, Mary Platell, Cameron Spilsbury, Katrina |
| author_facet | Theophilus, Mary Platell, Cameron Spilsbury, Katrina |
| author_sort | Theophilus, Mary |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Aim: Large randomized clinical trials comparing long-term survival after laparoscopic and open colectomy for large bowel cancer show equivalence, but meaningful analysis of data by stage has not been possible due to the small numbers of patients in individual trials. The aim of this meta-analysis was to improve statistical power by combining data to enable assessment of survival for individual stages. Method: A systematic review and meta-analysis was conducted through a computerized search of all randomized controlled trials comparing open and laparoscopic surgery for large bowel cancer. Overall survival data were analysed and subgroup analysis was performed for cancer of Stages I–III. Results: Five trials (3152 patients) were included. Overall survival was equivalent (hazard ration 0.93; 95% confidence interval 0.80–1.07). With each of the cancer stages, I–III, there was no difference in 5-year survival. There was, however, a nonsignificant trend in favour of open surgery in the subgroup analysis of Stage II patients. Conclusion: Laparoscopic-assisted surgery for colon cancer is equivalent to open surgery with respect to long-term survival although there may be a difference for Stage II cancer. |
| first_indexed | 2025-11-14T06:19:43Z |
| format | Journal Article |
| id | curtin-20.500.11937-8204 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:19:43Z |
| publishDate | 2014 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-82042019-02-19T05:35:28Z Long-term survival following laparoscopic and open colectomy for colon cancer: a meta-analysis of randomized controlled trials Theophilus, Mary Platell, Cameron Spilsbury, Katrina meta-analysis Colon laparoscopic surgery cancer Aim: Large randomized clinical trials comparing long-term survival after laparoscopic and open colectomy for large bowel cancer show equivalence, but meaningful analysis of data by stage has not been possible due to the small numbers of patients in individual trials. The aim of this meta-analysis was to improve statistical power by combining data to enable assessment of survival for individual stages. Method: A systematic review and meta-analysis was conducted through a computerized search of all randomized controlled trials comparing open and laparoscopic surgery for large bowel cancer. Overall survival data were analysed and subgroup analysis was performed for cancer of Stages I–III. Results: Five trials (3152 patients) were included. Overall survival was equivalent (hazard ration 0.93; 95% confidence interval 0.80–1.07). With each of the cancer stages, I–III, there was no difference in 5-year survival. There was, however, a nonsignificant trend in favour of open surgery in the subgroup analysis of Stage II patients. Conclusion: Laparoscopic-assisted surgery for colon cancer is equivalent to open surgery with respect to long-term survival although there may be a difference for Stage II cancer. 2014 Journal Article http://hdl.handle.net/20.500.11937/8204 10.1111/codi.12483 Wiley fulltext |
| spellingShingle | meta-analysis Colon laparoscopic surgery cancer Theophilus, Mary Platell, Cameron Spilsbury, Katrina Long-term survival following laparoscopic and open colectomy for colon cancer: a meta-analysis of randomized controlled trials |
| title | Long-term survival following laparoscopic and open colectomy for colon cancer: a meta-analysis of randomized controlled trials |
| title_full | Long-term survival following laparoscopic and open colectomy for colon cancer: a meta-analysis of randomized controlled trials |
| title_fullStr | Long-term survival following laparoscopic and open colectomy for colon cancer: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Long-term survival following laparoscopic and open colectomy for colon cancer: a meta-analysis of randomized controlled trials |
| title_short | Long-term survival following laparoscopic and open colectomy for colon cancer: a meta-analysis of randomized controlled trials |
| title_sort | long-term survival following laparoscopic and open colectomy for colon cancer: a meta-analysis of randomized controlled trials |
| topic | meta-analysis Colon laparoscopic surgery cancer |
| url | http://hdl.handle.net/20.500.11937/8204 |